Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

Resistance Training Clinical Trial

Official title:

Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04712578
• Other study ID #: IRB2020-813
• Secondary ID: 20-1299
• Status: Completed
• Phase: N/A
• Start date: February 23, 2021
• Est. completion date: May 11, 2021

Study information

• Verified date: June 2021
• Source: Texas Tech University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is a randomized, double-blind, placebo-controlled crossover trial examining the effects of caffeinated and non-caffeinated pre-workout supplements on resistance exercise performance. Resistance-trained adults will be randomly assigned to complete three study conditions (caffeinated pre-workout, non-caffeinated pre-workout, and placebo) in one of the six possible condition orders. During each condition, participants will report to the laboratory for ingestion of the assigned beverage and subsequent muscular performance testing. Major performance outcomes will be force production variables from a mechanized squat device and maximal strength and muscular endurance on the bench press and leg press exercises.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: May 11, 2021
• Est. primary completion date: May 11, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Between the ages of 18 and 40;
• Body mass between 50 - 100 kg (110-220 lb)
• Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplements or performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
• Resistance-trained, defined as completing 2+ resistance training sessions per week for at least three months prior to screening.
• Participants must have reported regular training of the lower body through a multi-joint exercise such as the squat or leg press at least once weekly during the three-month period prior to screening.
• Participants must have reported regular training of the bench press or chest press variation at least once weekly during the three-month period prior to screening.
• Female participants will be required to bench press = 0.5 x body mass and leg press = 1.75 x body mass during initial 1RM assessments to be eligible for this study.
• Male participants will be required to bench press = 1.0 x body mass and leg press = 3.0 x body mass to be eligible.
• Regular caffeine consumption (due to the presence of caffeine in the commercially available dietary supplement). This will be defined as an average self-reported daily intake of 250+ mg of caffeine, which is equivalent to approximately 2.5 cups of coffee.

Exclusion Criteria:

• Failing to meet any of the aforementioned inclusion criteria.
• Pregnant or breastfeeding (for female participants)
• Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes
• An inability to complete resistance exercise due to injury or medical condition
• Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.
• Allergy to any of the ingredients in the test beverages or standardized breakfast.
• Current use of anabolic steroids
• Presence of a pacemaker or other implanted electrical device.
• Unwillingness to wear the provided surgical mask during all testing procedures.

Related Conditions & MeSH terms

• Caffeine
• Dietary Supplements
• Resistance Training

Intervention

Dietary Supplement:
• Caffeinated pre-workout supplement
The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse caffeinated pre-workout supplement (Legion Athletics, Inc.).
• Non-caffeinated pre-workout supplement
The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse non-caffeinated pre-workout supplement (Legion Athletics, Inc.).
• Placebo
The intervention will consist of consuming a standardized meal followed by a placebo beverage.

Locations

Country	Name	City	State
United States	Department of Kinesiology & Sport Management	Lubbock	Texas

Sponsors (2)

Lead Sponsor	Collaborator
Texas Tech University	Legion Athletics, Inc

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Participant Identification of Beverage	At the end of each exercise session (i.e., after leg press testing has concluded), participants will be asked to identify the test beverage they believe they received.	At the very end of each condition (i.e., approximately 105 minutes after beverage ingestion in each condition; exact time of assessment may vary based on duration of exercise performance testing for each participant).
Primary	Isometric Peak Force Production	Peak isometric force produced on a mechanical squat device at an 120-degree knee angle.	Approximately 35 minutes after beverage ingestion in each condition.
Primary	Isometric Rate of Force Development	Rate of force development produced on a mechanical squat device at an 120-degree knee angle.	Approximately 35 minutes after beverage ingestion in each condition.
Primary	Isokinetic Peak Concentric Force Production	Peak concentric force produced during isokinetic testing on a mechanical squat device.	Approximately 40 minutes after beverage ingestion in each condition.
Primary	Isokinetic Peak Eccentric Force Production	Peak eccentric force produced during isokinetic testing on a mechanical squat device.	Approximately 40 minutes after beverage ingestion in each condition.
Primary	Maximal Strength on Bench Press Exercise	One-repetition maximum for the barbell bench press exercise.	Approximately 65 minutes after beverage ingestion in each condition.
Primary	Muscular Endurance on Bench Press Exercise	Repetitions to failure on the bench press exercise, using a load corresponding to 0.4 times body mass for females and 0.75 times body mass for males.	Approximately 70 minutes after beverage ingestion in each condition.
Primary	Maximal Strength on Leg Press Exercise	One-repetition maximum for the plate-loaded leg press exercise.	Approximately 95 minutes after beverage ingestion in each condition.
Primary	Muscular Endurance on Leg Press Exercise	Repetitions to failure on the leg press exercise, using a load corresponding to 1.5 times body mass for females and 2.5 times body mass for males.	Approximately 100 minutes after beverage ingestion in each condition.
Secondary	Subjective Ratings of Energy	Subjective rating of energy as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of energy).	Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.
Secondary	Subjective Ratings of Focus	Subjective rating of focus as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of focus).	Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.
Secondary	Subjective Ratings of Fatigue	Subjective rating of fatigue as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of fatigue).	Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.