Resistance Training Clinical Trial
Official title:
Comparison of Blood Flow Restriction Exercises With Conservative Exercises in Knee Osteoarthritis: A Randomized Controlled Single-Blind Study.
Verified date | March 2022 |
Source | Istanbul Medipol University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Knee osteoarthritis (OA) is a rheumatic disease that causes serious cartilage damage in the knee joint. Moderate physical activity can slow cartilage degeneration in moderate OA stages. Remarkable weakness and atrophy of the quadriceps and hamstrings is a common problem in patients with chronic osteoarthritis, but in arthritis, it may be difficult to achieve strength gains due to the pain caused by heavy load-resistant exercises. Exercising with these high loads may not be possible or may injure painful arthritic knees. For this reason, lately, blood flow restriction exercises have been directed to achieve the same gain by exercising with lower loads by restricting the blood flow with a cuff. We aimed to limit the blood flow in osteoarthritic knees and to provide strength gain and pain reduction provided by conventional exercises given routinely. Our hypothesis in this study is that exercises that blood flow restriction exercises will reduce pain and increase strength as well as conventional exercises.
Status | Completed |
Enrollment | 39 |
Est. completion date | February 11, 2022 |
Est. primary completion date | January 10, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 45 Years to 70 Years |
Eligibility | Inclusion Criteria: - Participants between the ages of 45-70, diagnosed with knee osteoarthritis according to the criteria of the American College of Rheumatology. - Participants who stated that the severity of knee pain to be evaluated with Visual Analog Pain Scale (VAS) is between 2-8 - Participants who are voluntaries for the study Exclusion Criteria: - Participants who have patellar subluxation or dislocation around the knee, who have other sources of knee pain such as bursae, fat pad and a history of knee surgery, - Those who are in Grade 1 or 4 according to the Kellgren-Lawrence radiographic staging - Those who have participated in leg weight exercise training in the last 6 months - Participants who are under the high risk of venous thrombosis (lower extremity surgery, cardiovascular conditions including high blood pressure (> 140/90) in the past 6 months), - Diabetes, pregnancy, unexplained chest pain or heart disease, fainting or dizziness during physical activity / exercise. - If exercise is contraindicated |
Country | Name | City | State |
---|---|---|---|
Turkey | Gizem Ergezen | Istanbul | Beykoz |
Lead Sponsor | Collaborator |
---|---|
Istanbul Medipol University Hospital |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pain Intensity | Pain intensities which are assessed by visual analogue scale(VAS) divided 10 equal intervals. "0" means no pain and "10" means unbearable pain. Higher scores idicate worse pain intensity. | 12 weeks | |
Primary | WOMAC score | score among patients with knee and/or hip osteoarthritis. The Index is self-administered, 24 question, 5-point Likert. Scores range from 0 to 96 for the total WOMAC where higher scores indicate worse function. | 12 weeks | |
Secondary | high sensitive C-reactive protein (hs-CRP) | hs-CRP(high sensitive C-reactive protein) level | 12 weeks | |
Secondary | Physical Function | measured by 6 minute walking test | 12 weeks | |
Secondary | Physical Function | measured by sit-stand test | 12 weeks | |
Secondary | Physical Function | measured by timed up and go test, | 12 weeks | |
Secondary | Quadriceps muscle strength | peak isometric knee extensor torque measured by myometer. | 4 weeks | |
Secondary | Quadriceps cross sectional area | Measured by MRI | 12 weeks | |
Secondary | Circumference of thigh | measured in the same level of quadriceps before and after application. | 12 weeks | |
Secondary | Short Form-36 questionnaire | SF-36 quality of life form | 12 weeks |
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