Residual Neuromuscular Blockade Clinical Trial
Official title:
Residual Neuromuscular Blockade in Cardiac Surgery Patients
Verified date | February 2022 |
Source | Henry Ford Health System |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this project is to determine if reversal of neuromuscular blockade in cardiac surgery patients expedites time to extubation in fast track patients.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | August 30, 2018 |
Est. primary completion date | August 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - All outpatients >18 years of age scheduled for elective coronary artery bypass graft surgery (CABG), aortic valve replacement (AVR), or combination CABG/AVR Exclusion Criteria: - Chronic kidney disease stage IV or V - Liver disease, defined as AST, ALT or ALP > 1.5x upper limit of normal Inpatient status - Allergy to rocuronium |
Country | Name | City | State |
---|---|---|---|
United States | Henry Ford Health Systems | Detroit | Michigan |
Lead Sponsor | Collaborator |
---|---|
Henry Ford Health System |
United States,
Richey M, Mann A, He J, Daon E, Wirtz K, Dalton A, Flynn BC. Implementation of an Early Extubation Protocol in Cardiac Surgical Patients Decreased Ventilator Time But Not Intensive Care Unit or Hospital Length of Stay. J Cardiothorac Vasc Anesth. 2018 Apr — View Citation
Zhu F, Lee A, Chee YE. Fast-track cardiac care for adult cardiac surgical patients. Cochrane Database Syst Rev. 2012 Oct 17;10:CD003587. doi: 10.1002/14651858.CD003587.pub2. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time from arrival in CVICU until extubation | through study completion, an average of 1 year | ||
Secondary | Tidal volumes prior to extubation | Prior to extubation, the tidal volumes the patient is generating will be documented | ||
Secondary | Need for unplanned noninvasive positive pressure ventilation or high flow nasal cannula | Assess how many liters of oxygen the patient requires to maintain pulse oximetry >92% | through study completion, an average of 1 year | |
Secondary | Lowest documented pulse oximetry | through study completion, an average of 1 year | ||
Secondary | Number of participants requiring re-intubation | If the patient is extubated in the intensive care unit but then develops respiratory failure and requires mechanical ventilation again | through study completion, an average of 1 year | |
Secondary | Bronchoscopy | Change in baseline oxygen requirements from prior to the surgery | through study completion, an average of 1 year | |
Secondary | Pneumonia | Change in baseline oxygen requirements from prior to the surgery | through study completion, an average of 1 year | |
Secondary | Intensive care unit length of stay | through study completion, an average of 1 year | ||
Secondary | Mortality | 28 days following the surgery |
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