Clinical Trials Logo
  1. Home
  2. Reperfusion Injury
  3. NCT00582010

Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation

Reperfusion Injury Clinical Trial

Official title:
Effects of Inhaled Nitric Oxide on Ischemia-Reperfusion Injury in Human Liver During Transplantation

Clinical Trial Summary

This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the restoration of blood flow. The premise of the current study is provided by previous studies which document a protective effect of inhaled nitric oxide in this clinical setting.

Clinical Trial Description

Specifically, presenting ischemia-reperfusion injury to transplanted livers remains a therapeutic goal in improving liver function and potentially expanding the number of transplantable livers. This study aims to assess the efficacy of inhaled nitric oxide to limit ischemia-reperfusion injury in transplanted livers and by doing so improve liver function post transplantation and decrease patient hospital length of stays. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00582010
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Completed
Phase Phase 2/Phase 3
Start date April 2008
Completion date October 2012
View Details
See also
  Status Clinical Trial Phase
Completed NCT02251041 - Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL) Phase 2
Completed NCT01944605 - Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest N/A
Completed NCT00994981 - Magnesium Administration in Liver Transplantation and Reperfusion Injury Phase 4
Completed NCT00529607 - Diagnostics for the Reperfusion Injury Following MI N/A
Completed NCT00778323 - Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery Phase 1/Phase 2
Completed NCT02731651 - Effect of Pneumoperitoneum on Human Ovary N/A
Completed NCT02286544 - Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers Phase 1
Active, not recruiting NCT00189007 - Antenatal Allopurinol During Fetal Hypoxia Phase 3
Completed NCT01167569 - Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients Phase 4
Completed NCT00246740 - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting Phase 2
Enrolling by invitation NCT05725694 - Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Completed NCT00402506 - A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG Phase 3
Completed NCT03176823 - Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury N/A
Completed NCT02512640 - Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery N/A
Recruiting NCT05574296 - Hydrogen's Feasibility and Safety as a Therapy in ECPR Phase 1
Active, not recruiting NCT02127996 - GLP-1 Loading During Elective Percutaneous Coronary Intervention Phase 2
Terminated NCT02394405 - Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Suspended NCT02850471 - Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery Phase 1/Phase 2
Completed NCT00516711 - Role of Volatile Anesthetics for Hepatic Protection N/A
Terminated NCT04316468 - Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation