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Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation

Inflammation Clinical Trial

Official title:
Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation

Clinical Trial Summary

In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03577249
Study type Interventional
Source Azienda Ospedaliera Città della Salute e della Scienza di Torino
Contact
Status Completed
Phase Phase 2/Phase 3
Start date October 30, 2014
Completion date July 30, 2015
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