HIV Infection Clinical Trial
Official title:
Incidence and Predictor of TDF Associated Nephrotoxicity and Pharmacokinetic of TDF in HIV-1 Infected Thai Patients: A Sub-study of HIV-NAT 006 Long Term Cohort
To assess and validate equation eGFR in HIV-infected subjects and -uninfected Thai patients
With significant reductions in mortality and risk of progression to AIDS with antiretroviral
therapy (ART), complications of long-standing HIV infection and treatment, including renal
disease, have become increasingly important. Aging, concomitant metabolic diseases, and use
of potentially nephrotoxic ART lead to higher risk for renal disease in HIV-infected
persons.WHO encourage TDF as first line ARV regimen. The data on TDF related renal toxicity
in Asian population is limited.
For this cohort, we plan to look at these topics:
1. proximal tubular dysfunction between TDF and non-TDF user
2. incidence and predictor of TDF related renal toxicity
3. TDF plasma concentrations
4. Pharmacokinetic of TDF when used with boosted DRV, boosted ATV, and boosted LPV in Thai
population
5. Bone density and vitamin D in patients with and without hypophosphatemia.
6. Pharmacogenomic of TDF in Thai population
;
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