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Renal Function clinical trials

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NCT ID: NCT05813730 Not yet recruiting - Renal Function Clinical Trials

Urinary Creatinine Excretion Time in the Neonatal Period

C-Rex
Start date: March 2024
Phase: N/A
Study type: Interventional

Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours of life, while at the same time it continues to produce its own creatinine. Therefore, the initial stock of creatinine at birth still increases through this production and the non or weak clearance. A better knowledge of renal physiopathology in newborns would allow to improve the therapeutic management of the infants, particularly in case of potential nephrotoxicity. No study has attempted to assess the increase in urinary creatinine excretion in neonates from a given time. Objectives: To show when urinary creatinine excretion in newborns is efficient. Results: this study mightr show an inflection point in urinary creatinine excretion illustrating the postnatal age when renal function becomes efficient.

NCT ID: NCT05503147 Recruiting - Aging Clinical Trials

Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)

CanPan
Start date: March 24, 2022
Phase: Phase 1
Study type: Interventional

Malnutrition and inappropriate prescribing of renally excreted drugs are common among older persons and are associated with severe consequences such as complicated courses of treatment, mortality, and reduced quality of life. The overall purpose of CanPan is to optimize treatment of older persons with malnutrition with a focus on appetite stimulation and optimized prescribing of renal risk drugs. The CanPan trial consists of two sub-studies. Substudy 1 will provide knowledge on appetite and appetite stimulation and together, sub study 1 and 2 will offer unique knowledge on how body composition, renal function and biomarkers of organ function influence pharmacokinetics for a highly lipophilic (Sativex®) and hydrophilic (Hexamycin®) drug in older medical patients with malnutrition.

NCT ID: NCT05179564 Completed - Acute Kidney Injury Clinical Trials

Renal Function Assessment in Critically Ill Children

IOHEXOL
Start date: May 20, 2018
Phase: N/A
Study type: Interventional

Identification of renal dysfunction in critically ill children is often delayed due to lack of accurate methods for evaluation of glomerular filtration rate (GFR). The investigators compared GFR measurement by the gold standard technique iohexol plasma clearance with estimated GFR (eGFR) based on selected established formulas incorporating the renal biomarkers creatinine, cystatin C and betatrace protein.

NCT ID: NCT04940260 Completed - Preeclampsia Clinical Trials

Soluble Factors and Renal Outcome in Preeclampsia

Start date: October 1, 2019
Phase:
Study type: Observational

Preeclampsia (PE) is an important complication of pregnancy and can lead to chronic kidney disease by causing endothelial damage and podocyte loss, Soluble forms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), sFlt1 / PlGF ratio and endoglin are the biomarkers for the differential diagnosis of preeclampsia and other diseases. We aim to explore the correlation of these biomarkers with long term renal function, blood pressure and urine albumin creatinine ratio (UACR) in PE patients.

NCT ID: NCT04742816 Completed - Renal Function Clinical Trials

Renal Effects of Hormones/Biomarkers in Transgender PrEP Recipients

Start date: September 17, 2020
Phase: Phase 4
Study type: Interventional

Will use a subset of the main study cohort of transgender or non-binary individuals to evaluate the relationships between self-reported exogenous hormone use, endogenous hormone values, renal biomarkers, drug levels and directly measured renal function.

NCT ID: NCT04334135 Recruiting - Blood Pressure Clinical Trials

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

MAVHS
Start date: October 2, 2020
Phase: N/A
Study type: Interventional

Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.

NCT ID: NCT03605810 Completed - Renal Function Clinical Trials

Study to Develop a Tool to Estimate the Kidney Function in Databases Without Laboratory Data

Start date: July 15, 2018
Phase:
Study type: Observational

Scientific analyses are frequently performed on e.g. health insurance databases to study the usage and effectiveness of drugs in real life. Kidney function is known to have an influence on a patients disease development and/or drug levels in blood. However, often direct measures for kidney function are not available in databases. This study plans to develop tools to classify the renal function of patients, which helps scientists to identify patient cohorts (groups of patients sharing same characteristics) for scientific analyses.

NCT ID: NCT03398889 Completed - Renal Function Clinical Trials

Intestinal Microbiome and Extremes of Atherosclerosis

Start date: July 1, 2014
Phase: N/A
Study type: Observational

Patients attending stroke prevention clinics and a premature atherosclerosis clinic at University Hospital in London, ON, Canada were recruited to the study. They completed a dietary questionnaire, provided stool samples and had blood drawn to measure plasma levels of metabolites produced by the intestinal bacteria.

NCT ID: NCT03228563 Completed - Clinical trials for Chronic Kidney Disease

The Effect of Probiotics on Chronic Kidney Disease

Start date: May 23, 2017
Phase: N/A
Study type: Interventional

Probiotics could attenuate renal function deterioration in CKD patients.

NCT ID: NCT03170739 Recruiting - Renal Function Clinical Trials

Effects of Dexmedetomidine and Dopamine on Renal Function After Major Surgery

Start date: June 6, 2017
Phase: Phase 4
Study type: Interventional

Acute kidney injury (AKI) is associated with complications that may lead to multiorgan dysfunction and potentially to multi-organ failure after major surgery. Dexmedetomidine is a highly selective alpha(2)-adreno receptor agonist widely used during anesthesia. In animals, dexmedetomidine has shown protective effects in AKI after surgery. Dopamine (DA) is an organic chemical of the catecholamine and phenethylamine families that has been widely used to increased renal blood flow and urine output during surgery. However, the clinical effects of dexmedetomidine and dopamine on renal function are still controversial. The aim of this study is to investigate whether dexmedetomidine and dopamine have positive effects on renal function after selective major surgery.