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NCT01135979 Clinical Trial

Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure

Renal Failure Clinical Trial

Official title:
Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT01135979
Other study ID # 07AN007
Secondary ID
Status Withdrawn
Phase N/A
First received June 2, 2010
Last updated March 5, 2013
Start date February 2010
Est. completion date December 2012

Study information
Verified date March 2013
Source University of Nottingham
Contact n/a
Is FDA regulated No
Health authority United Kingdom: Research Ethics Committee
Study type Observational

Clinical Trial Summary

The purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.

Description:

Aim

To quantify the degree of sympathetic blockade in the upper limb in patients with end stage renal failure produced during a regional anaesthetic technique, using laser Doppler flowmetry.

Hypothesis

Regional anaesthesia of the upper limb results in blockade of motor and sensory nerves, providing surgical and post-operative analgesia. Sympathetic nerves are also blocked resulting in local vasodilatation. This may be of benefit in surgery where enhanced blood flow is beneficial such as arterio-venous fistula creation. The degree and duration of sympathetic blockade produced by regional blocks however, has never been quantified. This study aims to quantify sympathetic blockade by measuring the changes in skin blood flow and skin temperature after placement of a brachial plexus block.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date December 2012
Est. primary completion date December 2012
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients with end stage renal failure

- Over 18 years of age

- Written consent obtained

- Due to undergo surgery for forearm fistula creation under a regional block

Exclusion Criteria:

- Smokers

- Damaged skin on the arm

- Circulatory disorders such as Raynaud's disease, systemic sclerosis, sickle cell trait or disease

- Current use of beta blockers

- undergoing haemodialysis for more than 12 months

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United Kingdom Nottingham University Hospitals NHS Trust Nottingham Nottinghamshire

Sponsors (1)
Lead Sponsor Collaborator
University of Nottingham

Country where clinical trial is conducted

United Kingdom, 

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