Renal Cell Carcinoma Clinical Trial
Official title:
A Phase I/II Evaluation of Cytokine Induced Killer Cells Stimulated by DC(DCIK) Immunotherapy in Patients With Renal Cell Carcinoma
30% of renal cell carcinoma patients have metastases, mostly in lung, liver and bones at the
time of diagnosis. Because of poor response to radiation therapy or chemotherapy, several
studies have been initiated to find alternative therapeutic options.
Cytokine induced killer cells(CIK) are an unique population of cytotoxic T lymphocytes with
a characteristic CD3+ CD56+ phenotype; they can be generated from cytokine cocktail-induced
peripheral blood mononuclear cells (PBMC). CIK cells represent strong anti-tumor
cytotoxicity in vitro and in vivo. Interestingly,the anti-tumor activity of CIK cells can be
enhanced by incubation with dendritic cells (DC), which are the most potent antigen
(Ag)-presenting cells.
The purpose of this study was to evaluate the clinical efficacy of DC-activated CIK cell
treatment following regular therapy and the effects of this therapy on immune responses in
patients with renal cell carcinoma after surgery.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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