Renal Cell Carcinoma Clinical Trial
Official title:
A Phase I, Multicenter, Open-Label, Dose-Escalation, Multidose Study of MDX-1203 in Subjects With Advanced/Recurrent Clear Cell Renal Cell Carcinoma or Relapsed/Refractory B-Cell Non Hodgkin's Lymphoma
The purpose of this study is to determine if MDX-1203 is safe for the treatment of renal cell carcinoma or non-hodgkin's lymphoma.
Multicenter, open-label, dose-escalation, multidose study of MDX-1203, a fully human
monoclonal antibody drug conjugate targeting the CD70 transmembrane cell-surface protein
which is highly expressed in ccRCC and B-NHL. MDX-1203 is composed of a human anti-CD70
monoclonal antibody covalently linked to a prodrug form of a cytotoxic deoxyribonucleic acid
(DNA) minor-groove binding agent (MGBA).
The study will consist of 3 periods: Screening (up to 28 days), Treatment (up to 17 cycles
or 2 years), and Follow-up (up to 6 months).
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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