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Clinical Trial Summary

This single center phase 1 trial will study the combination of nivolumab+ipilimumab with embolization in participants with renal cell carcinoma. The study will evaluate the safety of embolotherapy in patients with metastatic RCC receiving nivolumab+ipilimumab. The hypothesis is that the number of serious adverse events will be no greater than the number of serious adverse events for both therapies combined.


Clinical Trial Description

Previously untreated subjects with stage 4 RCC and unresected primary tumor or metastasis amenable to embolization will undergo two cycles of combination immune checkpoint inhibition (ICI) therapy, embolization of the target tumor, then resume ICI therapy. Study ends with safety and efficacy assessment at 6 months. Correlative blood and tissue specimens will be obtained. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04429321
Study type Interventional
Source Abramson Cancer Center at Penn Medicine
Contact
Status Terminated
Phase Phase 1
Start date August 26, 2020
Completion date January 31, 2024

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