Renal Calculi Clinical Trial
Official title:
Intraureteral of Alkalinized Lidocaine as Novel Approach to Post-Ureteroscopy Pain: Double-blind Prospective Randomized Controlled Trial
Ureteroscopy (URS) is minimally invasive procedure for management of renal stones. URS is
often involves concomitant of an indwelling ureteral stents. Placements of these stents
include pain, bladder irritability, infection, migration, encrustation and stones.
Pain is one of most significant problem of ureteral stents. There are no satisfactory
measures to deal with this problem. A novel approach to manage the pain is to load a drug
onto ureteral stent and deliver the drug into the urinary tract at controlled release rate.
Lidocaine has been proven to be effective for management of the pain associated with
interstitial cystitis. This agent has the potential for management of post-URS pain.
Status | Recruiting |
Enrollment | 48 |
Est. completion date | December 2013 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patient undergoing URS for treatment of a urinary calculus who requires placement of ureteral stent on a string - Able to undergo a general anaesthetic - At least 18 years old - Willing and able to complete patient symptom questionnaires Exclusion Criteria: - Solitary Kidney - Renal failure - Anatomic bladder or ureteral abnormality - Uncorrected coagulopathy - Previous cystectomy or urinary diversion - Neurogenic bladder - Interstitial cystitis - Transplanted kidney - Pregnancy - Requires an indwelling catheter - Recurrent urinary tract infections - Requires an indwelling stent - Pelvic kidney - Requires bilateral treatment/stents - Previous bladder or ureteral reconstructive surgery - Ureteral perforation during procedure - Ureteral stenting, within one month of URS - Known sensitivity to lidocaine - Febrile at time of randomization or treatment - Requires spinal anaesthetic |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Canada | Centre for Applied Urological Research/Kingston General Hospital | Kingston | Ontario |
Lead Sponsor | Collaborator |
---|---|
Queen's University |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pain as measured by the mean VAS pain score over the study period. | Pain as measured by the mean VAS pain score over the study period. VAS pain, urinary frequency, pain mediation diary and ureteral stent symptoms assessed at different time points during the study. Efficacy will be determined by a 2 or more point mean difference in pain scores between the active treatment group and placebo group. | 7 days | Yes |
Secondary | Establishment of safety of intraureteral administration of the alkalinized lidocaine solution | Comparison of safety parameters (adverse events) between placebo and treatment arm | 7 days | Yes |
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