Clinical Trials Logo

Renal Artery Obstruction clinical trials

View clinical trials related to Renal Artery Obstruction.

Filter by:

NCT ID: NCT01755858 Terminated - Clinical trials for Ischemia Reperfusion Injury

Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery

EVOLVE
Start date: December 2012
Phase: Phase 1/Phase 2
Study type: Interventional

This was a Phase 2a prospective, single center, randomized, double-blind, placebo-controlled study designed to assess the efficacy, pharmacokinetics, safety and tolerability of IV elamipretide for reduction of reperfusion injury in subjects with Atherosclerotic Renal Artery Stenosis (ARAS), who are undergoing percutaneous transluminal angioplasty of the renal artery (PTRA).

NCT ID: NCT01673373 Completed - Clinical trials for Renal Artery Stenosis

Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension

ARTISAN
Start date: October 23, 2012
Phase: N/A
Study type: Interventional

The purpose of this trial is to test how well the iCAST™ RX Stent works in patients diagnosed with atherosclerotic renal artery stenosis and whether or not increased blood flow by the stent will help to control blood pressure.

NCT ID: NCT01576835 Completed - Hypertension Clinical Trials

Renal Artery Contrast-Free Trial

REACT
Start date: February 2012
Phase: Phase 4
Study type: Observational

This study will compare the results of a clinically ordered abdominal CT angiography to a research non-contrast MR angiogram (MRA). CTA is a "gold-standard" for identifying blockages in the kidney arteries or other blood vessel problems. CTA requires radiation and contrast to obtain useful images. Conversely, the MR abdomen technique being used for the study uses no radiation or contrast and is felt to be a safer option for individuals who have kidney problems. there is benefit to establishing non-contrast MRA as a clinically accurate test.

NCT ID: NCT01344460 Completed - Clinical trials for Renal Artery Obstruction

Gadobutrol Enhanced MRA of the Renal Arteries

GRAMS
Start date: May 2011
Phase: Phase 3
Study type: Interventional

Subjects referred for a routine CTA (computed tomography angiography) or MRA (magnetic resonance angiography) will be invited to participate in the study and subjects will be involved in the study for between 2 and 12 days. Two to three visits to the study doctor will be required. This study will compare the diagnostic results of Gadobutrol enhanced MRA images with MRA images taken without contrast agent using images from a CTA as the standard of reference, which may have been performed up to 60 days prior to enrolment. If a CTA has not been performed in this prior time period, a CTA is required for the study. MRA and CTA images will be collected for an independent review (blinded read).

NCT ID: NCT01208714 Not yet recruiting - Clinical trials for Renal Artery Stenosis

Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study)

METRAS
Start date: December 2010
Phase: Phase 4
Study type: Interventional

Renal atherosclerotic stenosis (RAS) is a prevalent cause of secondary hypertension (HT). Since there are still uncertainties as to whether and in what patients revascularization by means of percutaneous renal angioplasty (PTRAS) should be pursued, we designed a study exploiting an optimized patient selection strategy and using hard experimental endpoints to unravel these uncertainties. Primary objective: to determine if revascularization by means of PTRAS is superior or equivalent to optimal medical treatment for preserving glomerular filtration rate in the ischemic kidney as assessed by 99mTcDTPA sequential renal scintiscan. Secondary objectives: to determine if the two treatments are equivalent in lowering blood pressure (BP), preserving overall renal function and regressing damage in the target organs of hypertension. Design: prospective multicenter randomized, unblinded two-arm study. Eligible patients will have clinical and/or radiological evidence of unilateral or bilateral RAS, defined by stenosis of the proximal portion of the renal artery and its main bifurcations at angioCT. Duplex scan will exclude nephroangiosclerosis as the latter could bias the assessment of the outcome of revascularization. Inclusion criteria. RAS affecting the main renal artery or its major branches at angio-CT either > 70% or, if < 70 with post-stenotic dilatation. Renal function will be assessed with 99mTc-DTPA renal scintigraphy. Sample size (30 patients per arm) was calculated to have a 90% power to detect a difference in means of GFR in the vascularized (or control untreated kidney) of 7.5 ml/min. Arms 1. Revascularization: digital scan angiography and PTA with stenting of the renal artery at the ostium or at truncular level, plus optimal medical therapy. 2. Medical therapy: the drug regimen that had been optimized during the run-in period. Experimental endpoints: The absolute value of GFR assessed by 99TcDTPA in the ischemic kidney will be used as quantitative variable and compared between groups at each time point. A categorical definition of kidney loss, defined as a GFR in the ischemic kidney of < 5 ml/min, will be also used and the rate of achievement of such endpoint will be compared. Duration: 5 years.

NCT ID: NCT01173666 Recruiting - Clinical trials for Left Ventricular Hypertrophy

Stenting of Renal Artery Stenosis in Coronary Artery Disease Study

RASCAD
Start date: April 2006
Phase: Phase 3
Study type: Interventional

The Stenting of Renal Artery Stenosis in Coronary Artery Disease (RASCAD) study is a randomized controlled trial designed to evaluate the effect of renal artery stenting+medical therapy versus medical therapy alone on left ventricular mass progression and cardiovascular morbidity and mortality in patients affected by coronary artery disease and renal artery stenosis.

NCT ID: NCT01128933 Completed - Hypertension Clinical Trials

Renal Fractional Flow Reserve in Renal Artery Stenting

PREFFER
Start date: June 2006
Phase: N/A
Study type: Interventional

The purpose of the study is to determine potential utility of renal fractional flow reserve in prognosis predicting after renal stent implantation.

NCT ID: NCT01057316 Completed - Clinical trials for Renal Artery Stenosis

Formula PTX Renal Stent Clinical Study

Start date: February 2010
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the safety and effectiveness of the PTX-coating on the Formula PTX Balloon-Expandable Stent in treatment of renal artery stenosis.

NCT ID: NCT01023373 Active, not recruiting - Clinical trials for Chronic Kidney Disease

Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy

NITER
Start date: October 2003
Phase: Phase 4
Study type: Interventional

The aim of the study is to value, in patients with chronic kidney disease and hypertension, whether medical therapy plus interventional renal artery revascularization is superior to medical therapy alone for the treatment of hemodynamically significant (>70%) atherosclerotic renal artery stenosis, diagnosed by duplex doppler ultrasonography and confirmed by magnetic resonance angiography, in terms of avoidance of the progression of renal damage, control of hypertension and in reducing the cerebro and cardiovascular complications.

NCT ID: NCT00885768 Completed - Clinical trials for Renal Artery Stenosis

Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization

RAS
Start date: July 2008
Phase: Phase 3
Study type: Observational

All patients referred for coronary angiography will simultaneously be evaluated for renal artery stenosis and then stenosis more than 50% will be analyzed according to clinical conditions, risk factors and lab data.