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Relative Bioavailability clinical trials

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NCT ID: NCT05296382 Completed - Clinical trials for Relative Bioavailability

Bioavailability of Tebipenem (SPR994) Crushed Tablet

Start date: April 1, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to measure the amount of the antibiotic, tebipenem (SPR994) that is bioavailable after crushing the tablet and administering through a feeding tube with and without tube feeds.

NCT ID: NCT04814472 Completed - Clinical trials for Relative Bioavailability

Healthy Volunteer Study Comparing Tablet and Oral Solution Formulations

Start date: May 16, 2021
Phase: Phase 1
Study type: Interventional

A Two-Part, Open-Label, Crossover, Bioavailability Study Comparing Tablet and Oral Solution Formulations of BLD-0409 in Healthy Volunteers

NCT ID: NCT04686669 Completed - Clinical trials for Relative Bioavailability

A Relative Bioavailability Study of FOR-6219 in Capsule and Tablet Formulations

Start date: December 10, 2020
Phase: Phase 1
Study type: Interventional

This is a phase 1, randomised, open-label, three-way, three-period, crossover relative bioavailability study to assess the single-dose pharmacokinetics of FOR-6219 in capsule and tablet formulations in postmenopausal women. The effect of high-fat food on the pharmacokinetics of the tablet formulation will also be evaluated. A total of twelve, post-menopausal women, will be randomised to receive a single oral dose of FOR-6219 in three treatment periods: capsule formulation (fasted); tablet formulation (fed); tablet formulation (fasted)

NCT ID: NCT03934333 Completed - Clinical trials for Relative Bioavailability

A Study to Compare the Pharmacokinetics of Budesonide Delivered by PT027 Compared With Pulmicort Flexhaler (ELBRUS)

Start date: May 16, 2019
Phase: Phase 1
Study type: Interventional

This study is to compare the systemic exposure of budesonide delivered by the combination inhaler (budesonide/albuterol sulfate pressurized inhalation suspension [BDA metered dose inhaler {BDA MDI}]) with Pulmicort Flexhaler dry-powder inhaler (DPI).

NCT ID: NCT03483259 Completed - Clinical trials for Relative Bioavailability

To Explore the Pharmacokinetics and Relative Bioavailability of Sulfatinib Capsules in Two Different Manufacturers

CRC-C1721
Start date: April 2, 2018
Phase: Phase 1
Study type: Interventional

This is a single-center, randomized, open, single-dose, three-cycle cross-design study, which will be only enrolled Chinese male healthy volunteers.

NCT ID: NCT02359045 Completed - Pharmacokinetics Clinical Trials

Study in Healthy Subjects to Compare the Concentrations of the Omega-3 Fatty Acids EPA and DHA in Blood When Delivered as Three New Capsules in Relation to the Epanova® Capsule Under Fasting and Fed Conditions

Start date: February 2015
Phase: Phase 1
Study type: Interventional

This study is a randomized, open-label, cross-over study in healthy subjects performed at a single study center. The study is divided into two parts, Part 1 and Part 2. The purpose of the study is to compare the pharmacokinetics (PK) of three different prototype capsule formulations (omega-3-carboxylic acids test formulations) with Epanova® capsules 1000 mg under fasted conditions in Part 1 and under fed conditions in Part 2. The results will be used as basis for choice of formulation for further pharmaceutical development.

NCT ID: NCT02052349 Completed - Clinical trials for Relative Bioavailability

Bioavailability of ABT-333 Within the Gastrointestinal Tract in Healthy Subjects

Start date: November 2013
Phase: Phase 1
Study type: Interventional

This open label, Phase 1 study is to investigate the relative bioavailability of ABT-333 when delivered within different sites of the gastrointestinal tract in 12 healthy subjects.

NCT ID: NCT01911741 Completed - Healthy Subjects Clinical Trials

A Study to Compare Capsule and Tablet Forms of MDV3100 (Enzalutamide) After Administration of a Single Set Dose Under Fasted Conditions in Healthy Male Subjects

Start date: November 2012
Phase: Phase 1
Study type: Interventional

A study to evaluate the bioavailability (BA) of a single oral dose of MDV3100 (enzalutamide) formulated as a solid spray dried tablet compared to oral liquid-filled capsules, and the safety and tolerability of oral formulations. Subjects are admitted to the clinic from days 1 to 5, followed by outpatient assessments up to Day 50. They return to the clinic for an end of study visit (ESV) 7-10 days after the last pharmacokinetic (PK) sampling or after early withdrawal.