Relapsing Multiple Sclerosis Clinical Trial
Official title:
Ofatumumab in Portuguese Multiple Sclerosis Patients - an Observational Study
This non-interventional study will compare the effect of Ofatumumab treatment between patients that began Ofatumumab within the 3 years after Multiple Sclerosis diagnosis and patients that began Ofatumumab with more than 3 years of Multiple Sclerosis diagnosis in a real-world setting in Portugal.
This is a 2 cohort, multi-center, observational study carried out in Portugal that aims to describe the effectiveness of Ofatumumab in a setting of routine medical care. Primary data will be collected from Multiple Sclerosis patients who initiate Ofatumumab early and later in their disease (cohorts 1 and 2, respectively). Data will be collected during 3 visits distributed over a maximum period of 24 months. Exceptionally, if the patient shows Expanded Disability Status Scale (EDSS) worsening in visit 2 or 3 (12 and 24 months after Ofatumumab initiation, respectively), there will be an additional visit 6±1 months after visit 2 or 3 for EDSS confirmation. The study includes patients that have initiated Ofatumumab up to 12 months prior inclusion in the study OR Patients that are initiating Ofatumumab at the moment of study inclusion. Patients in both cohorts will have to be treated with Ofatumumab for at least two years to compare No Evidence of Disease Activity (NEDA)-3 at 12 to 24 months, respectively. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04121065 -
Role of ADA SNPs in Subjects With Relapsing Multiple Sclerosis (RMS)
|
||
| Active, not recruiting |
NCT03996291 -
Long Term Safety and Efficacy Study of Tolebrutinib (SAR442168) in Participants With Relapsing Multiple Sclerosis
|
Phase 2 | |
| Recruiting |
NCT04510220 -
9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis
|
Phase 3 | |
| Terminated |
NCT02241785 -
Natalizumab as an Efficacy Switch in Participants With Relapsing Multiple Sclerosis (MS) After Failure on Other Therapies
|
Phase 4 | |
| Completed |
NCT02792218 -
Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis
|
Phase 3 | |
| Completed |
NCT01412333 -
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
|
Phase 3 | |
| Completed |
NCT03257358 -
A Study of Immune Phenotype Biomarkers in Patients With Relapsing Multiple Sclerosis (RMS) After Treatment With 0.5mg Fingolimod
|
Phase 4 | |
| Completed |
NCT01628393 -
Efficacy and Safety Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis Patients
|
Phase 2/Phase 3 | |
| Completed |
NCT04626921 -
A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT02234869 -
Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy
|
Phase 4 | |
| Withdrawn |
NCT05077956 -
Sema 4A as a Marker for Inflammatory Disease in Multiple Sclerosis
|
||
| Active, not recruiting |
NCT04486716 -
A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosis
|
Phase 3 | |
| Recruiting |
NCT04121403 -
Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS)
|
Phase 3 | |
| Terminated |
NCT00988052 -
A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course
|
Phase 3 | |
| Active, not recruiting |
NCT05232825 -
A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis
|
Phase 3 | |
| Terminated |
NCT01047319 -
A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosis
|
Phase 3 | |
| Completed |
NCT04847596 -
A Multicenter Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab
|
||
| Completed |
NCT01006941 -
Trichuris Suis Ova Therapy for Relapsing Multiple Sclerosis - a Safety Study
|
Phase 2 | |
| Completed |
NCT01127750 -
Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patients
|
Phase 3 | |
| Recruiting |
NCT06396039 -
A Study to Assess the Effectiveness and Safety of Ozanimod in Chinese Adults With Relapsing Multiple Sclerosis
|
Phase 4 |