Relapsed/Refractory Multiple Myeloma Clinical Trial
Official title:
A Phase 1, Multicenter, Open-Label Study of CB-011, a CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma (CaMMouflage Trial)
This is a Phase 1 study to evaluate the safety of CB-011 (the study treatment), an allogeneic chimeric antigen receptor (CAR-T) cell therapy that targets the B cell maturation antigen (BCMA), to determine the best dose of CB-011, and to assess the effectiveness of CB-011 in treating multiple myeloma that has come back (relapsed) or that is no longer responding to other treatment (refractory).
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Phase 1/Phase 2 | |
| Active, not recruiting |
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Phase 1 | |
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Universal BCMA-targeted LUCAR-B68 Cells in Patients With Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Recruiting |
NCT04973605 -
A Phase 1b/2 Study of BGB-11417in Monotherapy and in Various Combinations With Dexamethasone and Carfilzomib in Multiple Myeloma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05376345 -
BCMA-targeted LCAR-BCDR Cells in Patients With Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Withdrawn |
NCT05980507 -
An Open Label, Single-arm Clinical Study Evaluating the Safety and Efficacy of ICI201 Infusion in Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Active, not recruiting |
NCT04601935 -
A Single-center Exploratory Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of a BCMA-targeted Universal LCAR-BCX Cells in Patients With Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Terminated |
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Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM
|
Phase 1/Phase 2 | |
| Completed |
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Study of ISB 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT06049290 -
A Phase I/II Clinical Trial of LBL-034 in Patients With Relapsed Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05259839 -
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-383 in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Terminated |
NCT03318861 -
Study to Evaluate the Safety and Efficacy of KITE-585 in Participants With Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Active, not recruiting |
NCT03590652 -
Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone as Salvage Therapy in Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
| Completed |
NCT01794520 -
Study Evaluating ABT-199 in Participants With Relapsed or Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Terminated |
NCT04142619 -
Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01)
|
Phase 1 | |
| Completed |
NCT01849848 -
Study of SyB L-0501 to Treat Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
| Completed |
NCT01794507 -
A Study Evaluating ABT-199 in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy
|
Phase 1 | |
| Recruiting |
NCT05160584 -
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
|
||
| Terminated |
NCT03287908 -
A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT05862012 -
Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma
|
Phase 1 |