Relapsed/Refractory Multiple Myeloma Clinical Trial
Official title:
Randomized, Multicenter, Open-label, Phase III Study of Plitidepsin in Combination With Dexamethasone vs. Dexamethasone Alone in Patients With Relapsed/Refractory Multiple Myeloma
Study of Plitidepsin in combination with dexamethasone versus dexamethasone alone in patients with relapsed/refractory multiple myeloma.
Phase III Study in Patients with Relapsed/Refractory Multiple Myeloma to compare the efficacy of plitidepsin in combination with dexamethasone vs. dexamethasone alone measured by progression-free survival (PFS) and to evaluate tumor response, duration of response (DR), overall survival (OS) and to rule out any effect of plitidepsin on the duration of the QT/QTc interval (time corresponding to the beginning of depolarization to re-polarization of the ventricles). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Phase 1/Phase 2 | |
| Active, not recruiting |
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Phase 1 | |
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Universal BCMA-targeted LUCAR-B68 Cells in Patients With Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Recruiting |
NCT04973605 -
A Phase 1b/2 Study of BGB-11417in Monotherapy and in Various Combinations With Dexamethasone and Carfilzomib in Multiple Myeloma
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Phase 1/Phase 2 | |
| Recruiting |
NCT05376345 -
BCMA-targeted LCAR-BCDR Cells in Patients With Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Withdrawn |
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An Open Label, Single-arm Clinical Study Evaluating the Safety and Efficacy of ICI201 Infusion in Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Active, not recruiting |
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A Single-center Exploratory Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of a BCMA-targeted Universal LCAR-BCX Cells in Patients With Relapsed/Refractory Multiple Myeloma
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Phase 1 | |
| Terminated |
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Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM
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Phase 1/Phase 2 | |
| Completed |
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Study of ISB 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT06049290 -
A Phase I/II Clinical Trial of LBL-034 in Patients With Relapsed Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05259839 -
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-383 in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Terminated |
NCT03318861 -
Study to Evaluate the Safety and Efficacy of KITE-585 in Participants With Relapsed/Refractory Multiple Myeloma
|
Phase 1 | |
| Active, not recruiting |
NCT03590652 -
Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone as Salvage Therapy in Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
| Completed |
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Study Evaluating ABT-199 in Participants With Relapsed or Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Terminated |
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Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01)
|
Phase 1 | |
| Completed |
NCT01849848 -
Study of SyB L-0501 to Treat Relapsed/Refractory Multiple Myeloma
|
Phase 2 | |
| Completed |
NCT01794507 -
A Study Evaluating ABT-199 in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy
|
Phase 1 | |
| Recruiting |
NCT05160584 -
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
|
||
| Terminated |
NCT03287908 -
A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT05862012 -
Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma
|
Phase 1 |