Regulation of Muscle Protein Synthesis Clinical Trial
Official title:
Role of Leucine in the Regulation of Human Myofibrillar Protein Synthesis at Rest and Following Resistance Exercise
Muscle mass is normally maintained through the regulated balance between the processes of
protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old
muscle proteins). Proteins are composed of amino acids and we know that amino acids increase
muscle protein synthesis. However, not all amino acids are the same. Essential amino acids
are ones that must be consumed through food, while non-essential amino acids can be made by
our body. Interestingly, the essential amino acids are all that are required to increase the
rate of muscle protein synthesis. In addition, the essential amino acid leucine appears to be
particularly important in regulating protein synthesis. However, how leucine is able to
increase protein synthesis is not entirely understood. Previously, it has been shown that
20-25 g of high-quality protein, such as that found in milk, appears to be the amount of
protein that maximizes the rate of muscle protein synthesis after performing a bout of
resistance exercise. Thus, the aim is to measure the synthesis of new muscle proteins after
ingesting the following:
1. 25g whey protein
2. 6.25g whey protein supplemented with leucine
3. 6.25g whey protein supplemented with essential amino acids but no leucine
The investigators will measure muscle protein synthesis after consumption of the above
beverages in a leg that has done no exercise ( ie. a rested leg) and in the other leg that
has done resistance exercise. The hypothesis is that 6.25g whey supplemented with leucine
will stimulate muscle protein synthesis as effectively as 25g whey, but that 6.25g whey
supplemented will all the essential amino acids except whey will be less effective at
increasing muscle protein synthesis. Whey protein is a dairy-based protein found in cow's
milk, thus when you drink a glass of milk you are consuming some whey protein. However, the
investigators will be using an isolated form of whey protein, meaning it has been removed
from milk. As mentioned previously, amino acids are 'strung-together' to make protein. The
'essential' amino acids must be consumed through food because our body cannot make them, thus
they are consumed when you eat protein-rich foods like milk or chicken.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04565444 -
Ketones and Muscle Protein Synthesis
|
N/A |