Regional Blood Flow Clinical Trial
Official title:
Choroidal Blood Flow Regulation During Isometric Exercise: Effects of Ca2+-Channel Blockade
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in
perfusion pressure. For a long time it had been assumed that the choroid is a strictly
passive vascular bed, which shows no autoregulation. However, recently several groups have
identified some autoregulatory capacity of the human choroid. In the brain and the retina
the mechanism behind autoregulation is most likely linked to changes in transmural pressure.
In this model arterioles change their vascular tone depending on the pressure inside the
vessel and outside the vessel. In the choroid, several observations argue against a direct
involvement of arterioles. In a previous project we were able to identify that the nitric
oxide (NO) - system as well as the endothelin system are involved in choroidal blood flow
regulation during isometric exercise.
In the present study autoregulation of the choroid during isometric exercise will be
investigated and the pressure/flow relationships will be observed in the absence or presence
of a calcium antagonist - nifedipine.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01734616 -
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance in Older People
|
N/A | |
| Completed |
NCT00431691 -
Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
|
Phase 4 | |
| Completed |
NCT00810927 -
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
|
Phase 2 | |
| Completed |
NCT00431392 -
Mechanisms of Choroidal Blood Flow Changes During Dark/Light Transitions
|
Phase 2 | |
| Completed |
NCT00540215 -
GLP-2 (Glucagonlike Peptide-2) and Blood Flow
|
N/A | |
| Completed |
NCT02589054 -
Regional Changes in Upper Limb Perfusion Following Brachial Plexus Block: A Pilot Study
|
N/A | |
| Completed |
NCT00707226 -
Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes
|
N/A | |
| Completed |
NCT00709449 -
An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects
|
Phase 2/Phase 3 | |
| Terminated |
NCT00708357 -
Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?
|
Phase 0 | |
| Terminated |
NCT00709657 -
The Effect of a Single Intravitreal Anti-VEGF Therapy on Optic Nerve Head Perfusion
|
N/A | |
| Completed |
NCT00709423 -
Effects of Moxaverine and Placebo on Ocular Blood Flow
|
Phase 2 | |
| Completed |
NCT00814008 -
The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp
|
Phase 2 | |
| Completed |
NCT00708929 -
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid?
|
N/A | |
| Completed |
NCT00712400 -
Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects
|
N/A | |
| Completed |
NCT00312325 -
Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans
|
Phase 4 | |
| Withdrawn |
NCT00312390 -
Amblyopia and Neurovascular Coupling in the Retina of Humans
|
N/A | |
| Withdrawn |
NCT00406731 -
Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
|
Phase 2 | |
| Completed |
NCT00275730 -
Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
|
N/A | |
| Completed |
NCT00312416 -
Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
|
Phase 4 | |
| Completed |
NCT00712907 -
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
|
N/A |