Regional Blood Flow Clinical Trial
Official title:
A Randomized, Double-Masked, Placebo-Controlled Two Cross Over Study Comparing the Effects of Moxaverine and Placebo on Ocular Blood Flow
A number of common eye diseases such as retinal artery and vein occlusion, diabetic
retinopathy, age-related macular degeneration, glaucoma and anterior ischemic optic
neuropathy are associated with ocular perfusion abnormalities. Although this is well
recognized there is not much possibility to improve blood flow to the posterior pole of the
eye in these diseases.
Since many years, moxaverine is used in the therapy of perfusion abnormalities in the brain,
the heart and the extremities. This is based on a direct vasodilator effect of the drug, but
also on the rheological properties of red blood cells. Whether moxaverine affects blood flow
in the eye is unknown. The present study aims to investigate whether moxaverine may improves
blood flow in the eye after systemic administration.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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