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Clinical Trial Summary

This study is testing the safety and tolerability of BGB-21447 monotherapy in participants with relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study aims to determine the maximum tolerated dose (MTD), maximum adminstered dose (MAD), recommended Phase 2 dose (RP2D), and pharmacokinetic profile of the drug. Additionally, preliminary antitumor activity will be characterized. The study is divided into 2 main parts: Part 1 "Monotherapy Dose Finding" and Part 2 "Monotherapy Dose Expansion."


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Follicular
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Non-Hodgkin
  • Refractory Chronic Lymphocytic Leukemia
  • Refractory Diffuse Large B-cell Lymphoma
  • Refractory Follicular Lymphoma
  • Refractory Marginal Zone Lymphoma
  • Refractory Non-Hodgkin Lymphoma
  • Refractory Small Lymphocytic Lymphoma
  • Relapsed Chronic Lymphocytic Leukemia
  • Relapsed Follicular Lymphoma
  • Relapsed Non-Hodgkin Lymphoma
  • Relapsed Small Lymphocytic Lymphoma
  • Richter Transformation
  • Transformed Non-Hodgkin Lymphoma

NCT number NCT05828589
Study type Interventional
Source BeiGene
Contact BeiGene
Phone +1-877-828-5568
Email clinicaltrials@beigene.com
Status Recruiting
Phase Phase 1
Start date June 20, 2023
Completion date October 2026

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