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Anti-CD19 CAR T Infusion Combined With Allogeneic Stem Cell Transplantation for B-cell Leukemia/Lymphoma

Refractory Chronic Lymphocytic Leukemia Clinical Trial

Official title:
A Phase I Study of Administrating CD19 Chimeric Antigen Receptor Expressing T Cells Followed by Allogeneic Stem Cell Transplantation in Patients With Refractory CD19+ B-linage Leukemia/Lymphoma

Clinical Trial Summary

This is a single-arm open-label phase I study to determine the effect of CD19- CAR-T Cells infusion followed by allogeneic stem cell transplantation in safety, efficacy and engraftment potential in patients with CD19+ B-lineage leukemia and lymphoma.

Clinical Trial Description

Primary objectives

1. To determine the safety and feasibility of allogeneic stem cell transplantation combined with adoptive transfer of T cells modified to express CD19-specific chimeric antigen receptor (CD19CAR) for treatment of leukemia and lymphoma Secondary objectives

2. To measure the efficacy of the CD19CAR T cell infusion combined with allogeneic stem cell transplantation ;

Study Design

Related Conditions & MeSH terms

  • Adult Acute Lymphoblastic Leukemia in Remission
  • B-cell Adult Acute Lymphoblastic Leukemia
  • B-cell Chronic Lymphocytic Leukemia
  • Hematopoietic/Lymphoid Cancer
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Refractory Chronic Lymphocytic Leukemia
Clinical Trial Details
NCT number NCT03110640
Study type Interventional
Source First Affiliated Hospital of Wenzhou Medical University
Contact Kang Yu, M.D.
Phone 55578037
Email yukang62@126.com
Status Recruiting
Phase Phase 1
Start date October 1, 2016
Completion date September 2021
View Details
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