Refractory Chronic Lymphocytic Leukemia Clinical Trial
Official title:
A Phase I Study of Administrating CD19 Chimeric Antigen Receptor Expressing T Cells Followed by Allogeneic Stem Cell Transplantation in Patients With Refractory CD19+ B-linage Leukemia/Lymphoma
This is a single-arm open-label phase I study to determine the effect of CD19- CAR-T Cells infusion followed by allogeneic stem cell transplantation in safety, efficacy and engraftment potential in patients with CD19+ B-lineage leukemia and lymphoma.
Primary objectives
1. To determine the safety and feasibility of allogeneic stem cell transplantation combined
with adoptive transfer of T cells modified to express CD19-specific chimeric antigen
receptor (CD19CAR) for treatment of leukemia and lymphoma Secondary objectives
2. To measure the efficacy of the CD19CAR T cell infusion combined with allogeneic stem
cell transplantation
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