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Reflex, Abnormal clinical trials

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NCT ID: NCT05269602 Completed - Radiculopathy Clinical Trials

The Diagnostic Role of Adding the Hoffman Reflex Study for L5 Radiculopathy in the Electrodiagnostic Laboratory

Start date: December 1, 2017
Phase:
Study type: Observational

The H-reflex is one of the most popular topics in reflexology and one of the late responses involved in routine nerve conduction studies in the electromyography (EMG) laboratory. The H-reflex is generally recorded from the gastrocnemius-soleus muscles (tibial H-reflex) by stimulating the tibial nerve in the lower extremity. Tibial H-reflex is a sensitive measurement for examining S1 radiculopathy. Although there are plenty of studies related to the Soleus muscle registered H-reflex in S1 radiculopathy in the literature, there is no study in which the H-reflex is used in L5 muscles in diagnosing L5 radiculopathies. The aim of this study is to investigate the effectiveness of the H-reflex by using a different method in the distinction between L5 and S1 radiculopathies.

NCT ID: NCT05129982 Completed - Reflex, Abnormal Clinical Trials

Reliability of Methods for Determining the Vibration Threshold

IPMTRH
Start date: December 9, 2021
Phase: N/A
Study type: Interventional

It is known that whole-body vibration (TVV) has beneficial neuromuscular effects such as muscle strength increase. These beneficial effects are explained by the muscular reflex response induced by TVV. Reflex latency measurement is frequently used in clinical and neurophysiological research. The latency of the reflex response induced by TVV is defined as the period between the onset of the vibration stimulus and the onset point of the spike in the EMG signal. The current research aimed to determine whether the cumulative average method is reliable for estimating the EST.

NCT ID: NCT04543786 Terminated - Amputation Clinical Trials

Neuromodulation in Lower Limb Amputees

Start date: March 7, 2022
Phase: N/A
Study type: Interventional

The goal of this study is to investigate the role of transcutaneous spinal cord stimulation on spinal cord excitability in lower limb amputees. In this study, the investigators will quantify the spinal cord excitability determined by 1) reflexes and electromyography, and 2) phantom limb pain using self-reported pain assessments. The investigators will assess these measures of spinal excitability in lower limb amputees before and after transcutaneous spinal cord stimulation.

NCT ID: NCT04516798 Completed - Clinical trials for Reflex, Ankle, Decreased

The Reflex Mechanism Underlying Neuromuscular Effects Of The Whole Body Vibration

WBV-IRM
Start date: October 5, 2020
Phase: N/A
Study type: Interventional

This study was conducted to determine whether the spinal reflex mechanism underlying the neuromuscular effects of whole body vibration (WBV) is tonic vibration reflex. Local and whole body vibration reflex latencies were measured in young adult healthy volunteers.

NCT ID: NCT04347083 Completed - Reflex, Abnormal Clinical Trials

Determination of Onset Point of Mechanical Stimulation

TrueRL
Start date: April 13, 2020
Phase: N/A
Study type: Interventional

The difference between latencies of the tonic vibration reflex or T-reflex and whole body vibration-induced muscular reflex may be related to the distance between their stimulation point and the muscle spindles. Achilles tendon is mechanically stimulated by using a local vibrator to elicit the tonic vibration reflex or a reflex hammer to elicit the T-reflex. Whole body vibration, however, stimulates the soleus muscle indirectly over the heel, not directly, since whole body vibration is administered in a position that the subjects are standing on the whole body vibration platform. In other words, while the local vibrator or the hammer stimulates the Achilles tendon, whole body vibration stimulates the sole of the foot. During whole body vibration, mechanical vibration stimuli need to go a long way to reach the soleus muscle spindle. Therefore, whole body vibration-induced muscular reflex latency may be longer than tonic vibration reflex or T-reflex latency. The aim this study is to define a method for determination of onset point of mechanical stimulation inducing muscle spindle-based reflex (e.g., tonic vibration reflex, T-reflex) by using intramuscular electromyography electrodes.

NCT ID: NCT04268615 Completed - Healthy Volunteers Clinical Trials

Covert Saccade Triggers in Bilateral Vestibular Hypofunction

CS-TRIGGER
Start date: December 15, 2020
Phase: N/A
Study type: Interventional

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The triggering of these covert-saccade is still not known. They could be of visual origin but the short latency is unusual. The objective of this study is to evaluate the potential role of visual trigger in 12 patients with chronic bilateral areflexia, using different visuo-vestibular conditions. The latency of simple visually guided saccades will also be tested in the group of patients and a group of 12 healthy controls.

NCT ID: NCT04058184 Completed - Reflex, Abnormal Clinical Trials

Prepulse Inhibition in Youth Contact Sports Players

Start date: July 9, 2018
Phase:
Study type: Observational

The study's main research question will be investigating whether or not there is a significant difference in Prepulse Inhibition (PPI) as well as startle response probability and magnitude between contact and noncontact youth sports players. The study team will test these questions using a controlled laboratory scenario in which the presentation of startle stimuli can be observed, measured, and quantified in order to compare the results between the two sample populations. During preliminary testing, the study team can predict that there will be no significant differences between contact sports players and noncontact sports players in their startle reactivity and level of exhibited PPI. Based on previous literature, the study team hypothesizes that those in the contact sports group will experience greater startle reactivity and less PPI than those in the noncontact sports group when they are tested at the end of their sports season. Using this information, the present study will allow for additional understanding of the neurological and physiological behaviors associated with subconcussive head impacts. This study will assess and determine whether prepulse inhibition in youth contact sports players and non-contact sports players, both before and after a sports season, will significantly differ. Measures will include the startle magnitude, startle probability, reaction time, and accuracy of tone detection responses.

NCT ID: NCT04005937 Completed - Muscle Hypertonia Clinical Trials

Optimal Interstimulus Interval For Consecutive H-Reflex Responses In Patients With Spasticity

Start date: June 30, 2019
Phase: N/A
Study type: Interventional

This study evaluates the optimal interstimulus interval for consecutive H-reflex responses in patients with spasticity.

NCT ID: NCT03755089 Recruiting - Clinical trials for Urinary Incontinence

Oral vs Intravesical Analgesia for Office Bladder Botox Injections

OPIL
Start date: November 1, 2018
Phase: Phase 4
Study type: Interventional

OnabotulinumtoxinA (Botox®) bladder injections are a highly effective treatment for overactive bladder and urgency urinary incontinence. The procedure is typically performed in the office setting with one of two medications to control comfort. However, the effectiveness of these medications has never been compared. The goal of this study is to determine which medication is better at providing comfort during bladder Botox® injections.

NCT ID: NCT02994030 Completed - Clinical trials for Duchenne Muscular Dystrophy

Biomarker for Duchenne Muscular Dystrophy

BioDuchenne
Start date: August 20, 2018
Phase:
Study type: Observational

International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.