Improvement in Function Clinical Trial
Official title:
Methotrexate in Hand Osteoarthritis
Osteoarthritis (OA) is a common disabling condition, for which no effective therapy currently
exists. Synovitis has been demonstrated in hand OA imaging. Synovial inflammation due to the
release of cytokines is an important cause of pain. Methotrexate (MTX) helps to decrease
synovitis in many inflammatory joint diseases, particularly rheumatoid arthritis.
The aim of the present study is to assess the efficacy of MTX in decreasing pain and
inflammation in symptomatic hand OA.
Methods: One hundred and twenty patients with American College of Rheumatology (ACR) clinical
and radiographic criteria of primary knee OA with hand pain, [>4 on the 24-hour average pain
severity scale (0-10) using mean of daily ratings from week preceding randomization] for > 14
days/month during 3 consecutive months preceding enrollment will be included in this
randomized double-blind placebo-controlled trial. Patients meeting the eligibility criteria
were randomized in a 1:1 ratio to receive either 25mg/week oral MTX (n=60) or placebo (n=60)
together with their usual therapy provided the dosages were kept constant for 28 weeks. Pain
will be assessed using the Visual Analogue pain Scale, (VAS, 0-100 mm). Functional assessment
will be performed using the Western Ontario and McMaster Universities Osteoarthritis Index
(WOMAC) and Activities of daily living (ADL) scores. Alterations in dosage of analgesic/NSAID
drugs used will be recorded. Safety and tolerability will also be assessed. Synovitis will be
detected by ultrasound imaging.
n/a