Hemorrhage Clinical Trial
Official title:
Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage
Postoperative vitreous hemorrhage is a common complication after vitrectomy for
proliferative diabetic retinopathy. There have been efforts to lower the incidence of
postoperative vitreous hemorrhage such as preoperative bevacizumab injection. Bevacizumab
(Avastin) is a potent inhibitor of angiogenesis and has been shown to decrease retinal and
iris neovascularization in proliferative diabetic retinopathy. Recently there have been
reports showing that preoperative bevacizumab injection could reduce intraoperative bleeding
from abnormal vessels and could make surgery easier and more successful. Our hypothesis is
that intraoperative bevacizumab injection could reduce postoperative vitreous hemorrhage by
inhibiting the vessel formation after surgery.
We started the prospective randomized comparative study to determine the effect of pre and
intra-operative bevacizumab injection on postoperative vitreous hemorrhage after diabetic
vitrectomy in comparison to vitrectomy without any adjuvant drug.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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