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Periurethral vs Intravaginal Estrogen for Prevention of Recurrent Urinary Tract Infections — TAPER  

Recurrent Urinary Tract Infection Clinical Trial

Official title:
Periurethral vs Intravaginal Estrogen for Prevention of Recurrent Urinary Tract Infections: TAPER (Techniques of APplying Vaginal Estrogen for Prevention of Recurrent Urinary Tract Infections) Trial

Clinical Trial Summary

Due to rising antibiotic resistance, there has been a focus on non-antibiotic prophylactic measures for postmenopausal patients with recurrent urinary tract infections (rUTI), one of which is the safe and efficacious option of vaginal estrogen therapy. Standard application of vaginal estrogen cream entails intravaginal application of the cream twice a week, but some providers counsel patients with rUTI to apply a small, pea-sized amount to the periurethral area. This ideally reduces the amount of vaginal estrogen used while attaining a similar effect. However, to date, there is no data to prove that the periurethral technique of application is similar or non-inferior to intravaginal application in preventing UTI.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05472779
Study type Interventional
Source University of Pittsburgh
Contact Stephanie W Zuo, MD
Phone 412-270-4818
Email zuos@upmc.edu
Status Recruiting
Phase Phase 2
Start date January 3, 2023
Completion date January 1, 2025
View Details
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