Recurrent Rectal Cancer Clinical Trial
Official title:
A 2 Phase Comparison of Pre-operative CT AND PET Images in the Intraoperative Detection of Disease to a Hand-held Probe, and to an Intraoperative CT Scan in Patients Undergoing Surgery for Metastatic Colorectal Cancer.
This pilot phase II studies how well computed tomography (CT) and positron emission tomography (PET) imaging works in detecting disease in patients undergoing surgery for metastatic colorectal cancer. Diagnostic procedures, such as CT and PET scans, done before and during surgery may help find colorectal cancer and help guide surgery
PRIMARY OBJECTIVES:
I. To determine the feasibility of rigidly (linearly) registering PET to CT images and
applying this fused dataset to guide surgery with an image-guided navigation system and a
handheld positron probe in order to facilitate disease detection and improve resection
accuracy in advanced stage colorectal cancer.
II. To complete development of software for the nonlinear registration of PET and CT
datasets.
OUTLINE:
Patients undergo preoperative whole-body PET scans and CT scans of the abdomen and pelvis.
Patients then receive 18 F fludeoxyglucose (FDG) intravenously (IV) 60-90 minutes prior to
surgery and undergo intraoperative CT scans using a handheld probe and computer navigation
system.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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