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Clinical Trial Summary

In 50% of women with recurrent pregnancy loss (RPL) miscarriages are unexplained, therefore no therapeutic intervention is possible. In a pilot study, women with unexplained RPL showed less endometrial NK cells (eNK) compared to women with a previously uncomplicated pregnancy. It is known that eNK cells are important for embryo implantation during early pregnancy. Investigators presume that high sympathetic activity in these women is related to eNK cell number, function and phenotype and that exercise is an effective intervention to lower sympathetic activity and to influence the immune system, as especially peripheral NK cells have been assumed to be responsive to physical training. The investigators hypothesize that moderate exercise can lower the adrenergic tone of the sympathetic nervous system hereby influencing endometrial NK cells in women with RPL and eventually pregnancy outcome.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06007560
Study type Interventional
Source Radboud University Medical Center
Contact Tess Meuleman, Dr. MD.
Phone 0031-631133392
Email tess.meuleman@radboudumc.nl
Status Recruiting
Phase N/A
Start date March 21, 2022
Completion date August 2024

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