Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

Recurrent Pregnancy Loss Clinical Trial

Official title:

Endoplasmic Reticulum Stress in Recurrent Pregnancy Loss

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04455256
• Other study ID #: tgk-xbp
• Status: Completed
• Start date: March 20, 2020
• Est. completion date: July 7, 2020

Study information

• Verified date: July 2020
• Source: Kanuni Sultan Suleyman Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: July 7, 2020
• Est. primary completion date: July 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• with three or more miscarriages before 20 th week of gestation

• had no chronic or acute inflammatory disease

• used no steroids, anti-inflammatory, or antioxidant medications

Exclusion Criteria:

• had inflammatory diseases

• had systemic disease

• Anatomical abnormalities, infectious, endocrine, or genetic etiologies

Related Conditions & MeSH terms

• Abortion, Habitual
• Abortion, Spontaneous
• Endoplasmic Reticulum Stress
• Fetal Death
• Recurrent Pregnancy Loss

Intervention

Other:
• x box binding protein
Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Locations

Country	Name	City	State
Turkey	Pinar Yalcin Bahat	Istanbul	I?stanbul

Sponsors (1)

Lead Sponsor	Collaborator
Kanuni Sultan Suleyman Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Show the effect of endoplasmic reticulum stress on recurrent pregnancy loss	Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.	3 months