Recurrent Miscarriage Clinical Trial
Official title:
Study on the Association Between Skewed X Chromosome Inactivation(SXCI) and Recurrent Miscarriage(RM) and the Possible Genetic Mechanism
To determine whether there is higher incidence of skewed X chromosome inactivation(SXCI) in the recurrent miscarriage(RM) population compared with normal population, and verify the existing hypothesis of the possible genetic mechanisms underlying the association between SXCI and RM.
Recurrent spontaneous abortion (RSA), defined as 2 or more consecutive pregnancy losses before 20-22 weeks of gestation, is a multifactorial disorder that affects about 5% of all couples.In up to 50% of women who have experienced RSA, the cause still remains unexplained, with genetic problem proposed as a main cause. X chromosome inactivation (XCI) is a physiological phenomenon in female mammals for 'dosage compensation' of X-linked genes with males. A normal female is mosaic, with about one-half of her somatic cells expressing the paternal derived X and the remainder of her cells using maternal X. In some situations, however, the inactivation is not random, resulting in a female having most or even all her somatic cells inactivating the same X chromosome from either paternal or maternal resource, which is known as skewed X-chromosome inactivation (SXCI).Evidence of an association between skewed X chromosome inactivation (SXCI) and idiopathic recurrent spontaneous abortion (RSA) is conflicting. This is a single-center observational case-control trial to determine whether there is higher incidence of skewed X chromosome inactivation(SXCI) in the recurrent miscarriage(RM) population compared with normal population, and verify the existing hypothesis of the possible genetic mechanisms underlying the association between SXCI and RM. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT01419392 -
Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages
|
Phase 4 | |
Completed |
NCT00193674 -
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
|
Phase 3 | |
Completed |
NCT06001060 -
Distinct Alterations in Gut Microbiota Composition Among Women of Reproductive Age With Elevated Homocysteine Levels.
|
||
Recruiting |
NCT05034250 -
Iron Status in Female Infertility and Recurrent Miscarriage
|
||
Completed |
NCT02681627 -
Sim (Scratch in Miscarriage) Study
|
N/A | |
Recruiting |
NCT02303171 -
Use of Warfarin After the First Trimester in Pregnant Women With APS
|
Phase 4 | |
Completed |
NCT02305420 -
EmbryoGen/ Blastgen for Couples With Implantation Problems or Previous Miscarriage
|
Phase 4 | |
Recruiting |
NCT05824897 -
The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome
|
||
Completed |
NCT03023137 -
Walking and Dietary Modification for Recurrent Early Miscarriages
|
N/A | |
Not yet recruiting |
NCT03132779 -
Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
|
Phase 1 | |
Completed |
NCT02184741 -
A Study of the Efficacy and Safety of GB-0998 in Patients With Unexplained Recurrent Miscarriage
|
Phase 3 | |
Active, not recruiting |
NCT02156063 -
A Multi-center, Placebo-controlled Study to Evaluate NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)
|
Phase 2 | |
Recruiting |
NCT03902912 -
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
|
Phase 3 | |
Not yet recruiting |
NCT03209063 -
The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
|
||
Completed |
NCT03970954 -
Low-dose Interleukin-2 in Women With Unexplained Miscarriages
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT06249230 -
The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk
|
||
Recruiting |
NCT05725512 -
Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages
|
Phase 4 | |
Recruiting |
NCT05267678 -
Nutritional Deficiency and Recurrent Miscarriage
|
||
Completed |
NCT02694367 -
Expression of EPK in Recurrent Miscarriage
|
N/A | |
Completed |
NCT01608347 -
Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies
|
Phase 4 |