Analysis of the Curative Effect of Salvage Surgery on Recurrent Laryngeal Carcinoma

Recurrent Laryngeal Carcinoma Clinical Trial

Official title:

Analysis of the Curative Effect of Salvage Surgery on Recurrent Laryngeal Carcinoma: A Single-institutional Experience

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03604601
• Other study ID #: recurrent laryngeal carcinoma
• Status: Completed
• Start date: June 1, 2016
• Est. completion date: June 1, 2018

Study information

• Verified date: July 2018
• Source: First Affiliated Hospital, Sun Yat-Sen University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Early laryngeal cancer can be treatment by laser surgery or radiotherapy, intermediate and advanced laryngeal carcinoma mainly surgical treatment. Laryngeal cancer is at risk of recurrence after treatment, whether in surgery, laser or radiotherapy. The recurrence rate of laryngeal cancer is about 10% reported at home and abroad. Local pain, ulcers, breathing and eating difficulties caused by recurrent laryngeal cancer seriously reduce the quality of life of patients and seriously endanger their lives. Therefore, head and neck surgeons are required to make every effort to give them saving treatment in order to improve their quality of life. Prolong the patient's life.

Description:

medical records and extracted information including age, gender, initial treatment modality of glottis cancer, recurrence time, recurrence site, histopathology, tumor grade according to World Health Organization (WHO) grade and tumor stage. Stages were defined according to the American Joint Committee on Cancer (AJCC) staging system.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: June 1, 2018
• Est. primary completion date: June 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• more than 18 years,

• patients with recurrent glottic laryngeal squamous cell carcinoma undergoing salvage surgery

Exclusion Criteria:

• postoperative radiotherapy and chemotherapy

• loss to follow-up

Related Conditions & MeSH terms

• Carcinoma
• Laryngeal Neoplasms
• Recurrent Laryngeal Carcinoma

Intervention

Procedure:
• salvage surgery
Salvage surgery hopes to control the recurrence of larynx, pharynx, fistula and neck tumor and improve the quality of life and survival rate

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
First Affiliated Hospital, Sun Yat-Sen University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	overall survival (OS)	The overall survival rate was calculated with Kaplan-Meier method.	Follow up 5 years