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RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

Recurrent Glioblastoma Clinical Trial

Official title:
A Phase I Study of RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

Clinical Trial Summary

This is a Phase I study to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in adult patients with recurrent glioblastoma.

Clinical Trial Description

This is a first in human Phase I study of RNA-LP vaccines for recurrent adult glioblastoma. Patients will be randomized 1:1 to receive RNA-LP starting either before (Arm 1) or after tumor biopsy/resection (Arm 2). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06389591
Study type Interventional
Source University of Florida
Contact Marcia Hodik
Phone 352-273-9000
Email marcia.hodik@neurosurgery.ufl.edu
Status Not yet recruiting
Phase Phase 1
Start date December 2024
Completion date December 2028
View Details
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