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Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Patients With Recurrent Posterior Fossa Ependymoma — 5-AZA  

Recurrent Ependymoma Clinical Trial

Official title:
Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle or Resection Cavity in Children and Adults With Recurrent Posterior Fossa Ependymoma: A Phase I Study

Clinical Trial Summary

This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA) infusions into the fourth ventricle of the brain. The study's primary objective is to establish the maximum tolerated dose for infusions of 5-Azacytidine into the fourth ventricle in patients with recurrent ependymoma. The study's secondary objective is to assess the antitumor activity of 5-Azacytidine infusions into the fourth ventricle based upon imaging studies and cytology.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03572530
Study type Interventional
Source The University of Texas Health Science Center, Houston
Contact Bangning Yu, MD, PhD
Phone 713-500-7363
Email Bangning.Yu@uth.tmc.edu
Status Recruiting
Phase Phase 1
Start date February 8, 2019
Completion date December 1, 2025
View Details
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