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Recurrent Ependymoma clinical trials

View clinical trials related to Recurrent Ependymoma.

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NCT ID: NCT03572530 Recruiting - Clinical trials for Recurrent Ependymoma

Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Patients With Recurrent Posterior Fossa Ependymoma

5-AZA
Start date: July 1, 2018
Phase: Phase 1
Study type: Interventional

This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA) infusions into the fourth ventricle of the brain. The study's primary objective is to establish the maximum tolerated dose for infusions of 5-Azacytidine into the fourth ventricle in patients with recurrent ependymoma. The study's secondary objective is to assess the antitumor activity of 5-Azacytidine infusions into the fourth ventricle based upon imaging studies and cytology.

NCT ID: NCT00634231 Active, not recruiting - Malignant Glioma Clinical Trials

A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors

Start date: April 2010
Phase: Phase 1
Study type: Interventional

This study will evaluate the administration of AdV-tk followed by valacyclovir in children with malignant glioma, including glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA), as well as recurrent ependymomas in combination with radiation therapy. The primary objective is to determine if this approach is safe and can be effectively delivered without disturbing standard therapy.