Recurrent Childhood Acute Lymphoblastic Leukemia Clinical Trial
Official title:
OBSERVATIONAL: Replication Profiling as a Diagnostic Tool in B-cell Acute Lymphoblastic Leukemia (ALL)
This clinical trial is studying biomarkers as a diagnostic tool in samples from younger patients with B-cell acute lymphoblastic leukemia. Finding specific biomarkers may help improve the treatment of patients with B-cell acute lymphoblastic leukemia
STUDY SUBTYPE: Ancillary/Correlative
OBSERVATIONAL STUDY MODEL: Case-only
TIME PERSPECTIVE: Retrospective
BIOSPECIMEN RETENTION: Samples with DNA
BIOSPECIMEN DESCRIPTION: Fresh and frozen bone marrow cells
STUDY POPULATION DESCRIPTION: Patients with B-cell acute lymphoblastic samples banked at the
COG Cell Bank
SAMPLING METHOD: Non-probability sample
OBJECTIVES:
I. To determine whether we can identify individuals within a specific sub-group of pre-B
acute lymphoblastic leukemia (ALL) patients that will eventually recur.
II. To identify replication-timing changes as a biomarker for further risk prediction.
III. To identify differences between patients of similar subtype, and choose candidate
differences to analyze by methods that are compatible with frozen samples.
OUTLINE:
Archived cell samples are analyzed for replication timing by flow cytometry, microarray, and
single-cell fluorescence in situ hybridization (FISH) assays. Replication-timing results
among cases and controls are also analyzed.
;
Time Perspective: Retrospective
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