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Clinical Trial Summary

This is a two-arm, open label, randomized phase II clinical study. The aim is to evaluate the safety and efficacy of Cadonilimab (a PD-1/CTLA-4 bispecific antibody) combined with XELOX regimen in pMMR locally advanced rectal cancer during the perioperative period. Eligible patients will receive either Cadonilimab plus XELOX or XELOX alone for 4 cycles before and 4 cycles after surgery. The primary endpoint is the pathological complete response rate.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05815303
Study type Interventional
Source Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Contact Aiping Zhou, M.D.
Phone 86-10-87788800
Email zhouap1825@126.com
Status Recruiting
Phase Phase 2
Start date March 29, 2023
Completion date March 2026

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