Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior

Status Not yet recruiting

Clinical Trial Summary

Effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery: a prospective, multicenter, randomized controlled study (ARVECTS)

Clinical Trial Description

Several studies have demonstrated that the presence of circulating tumor cells (CTCs) in the peripheral blood can be a surrogate biomarker to predict recurrence and prognosis of rectal cancer. CTCs are released from the primary tumor into the bloodstream and have the potential to spread to distant sites and develop into micro-metastatic deposits. Numerous studies have demonstrated that surgical manipulation could promote the dissemination of tumor cells into the circulation. Theoretically, the potential risk of tumor cell dissemination can theoretically be minimized if the effluent vein was ligated first. However, there is no regulation in the current guidelines on the sequence of ligation of the inferior mesenteric artery and vein during rectal cancer surgery owing to a lack of sufficient evidence. This multi-center randomized controlled trial is to investigate effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05807646
Study type	Interventional
Source	Sichuan Cancer Hospital and Research Institute
Contact	Tao Pan, Doctor
Phone	+86-18181986821
Email	taopancd@163.com
Status	Not yet recruiting
Phase	N/A
Start date	January 2025
Completion date	December 2028

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Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms