Clinical Trial Summary
AIM OF RESEARCH. The aim of our research is to improve the results of the combined treatment
of patients with locally advanced rectal cancer using endovascular methods and reservoir and
plastic surgery.
TASKS OF RESEARCH.
1. To assess the immediate and long-term results of combined (chemoradiation and surgical)
treatment for locally advanced rectal cancer.
2. To make a comparative evaluation of the results of independent surgical and combined
(chemoradiation and surgery) treatment of patients with locally advanced rectal cancer.
3. To examine functional results of surgical treatment with the formation of "neosphincter"
and "neorectum" in patients with colorectal cancer..
4. To study features of blood supply to the rectum from the pools of the inferior
mesenteric and internal iliac arteries, using the method of selective angiography, in
connection with the development of endovascular treatment of rectal cancer.
5. To develop and introduce into clinical practice method of one-stage selective
intra-arterial oil chemoembolization of upper, middle and lower rectal arteries in
patients with locally advanced rectal cancer, who have a contraindication to
preoperative radiotherapy.
6. To assess the immediate and long-term results of combined (endovascular and surgical)
treatment for locally advanced rectal cancer.
7. To optimize tactics of combined treatment of locally advanced rectal cancer by
developing an algorithm of using chemoradiotherapy and endovascular interventions in the
preoperative period.
NOVELTY OF RESEARCH.
1. As a result of research will be designed and implemented a new method of selective
intra-arterial chemoembolization in rectal arteries preoperatively in patients with
locally advanced rectal cancer.
2. Substantiated high effectiveness of the proposed technique for the removal of colonic
obstruction and, as a consequence perform radical surgical treatment of these patients.
3. First developed dosage and concentration of chemotherapeutic agent and embolic agent for
safe injection when performing selective intra-arterial chemoembolization of rectal
arteries.
4. Developed complex techniques of selective intra-arterial chemoembolization of rectal
arteries preoperatively in patients with locally advanced rectal cancer.
5. Will be made a comparative analysis of the postoperative period and the evaluation of
the quality of life of operated patients Obtained data will be presented for use in
clinical practice. POSSIBLE APPLICATION AREAS. Results of the research designed for use
in the treatment process of departments of Coloproctology, oncology, as well as the
educational process of higher and secondary medical institutions.
EXPECTED EFFECTIVENESS.
It is expected that the use of this method of treatment of patients with locally advanced
rectal cancer in clinical practice will provide pronounced effect:
1. Medical and social - improving the quality of care, preservation of social activity of
patients, reducing mortality;
2. Economic - reducing the time of patients' treatment and reducing the number of
therapeutic manipulation;
3. Science and Technology - improving of the training level of medicine workers in the
treatment of patients with rectal cancer.
