Rectal Cancer, Adenocarcinoma Clinical Trial
Official title:
Investigation of the Value of ctDNA Analysis in the Diagnosis, Treatment, and Surveillance of Patients With Surgically Resectable Colorectal Cancer
In this study, we aim to investigate the value of circulating tumor DNA (ctDNA) analysis in the diagnosis, treatment, and surveillance of patients with surgically resectable colorectal cancer, by performing serial analysis of ctDNA, next-generation sequencing of surgical specimens, and observation of patients undergoing radical resection of the tumor with or without adjuvant chemo- and/or radiotherapy.
A prospective, observational study to determine the value of circulating tumor DNA (ctDNA)
for predicting the therapeutic effects of the combined modality treatment for colorectal
cancer and the patients' long-term prognosis.
Research objects: patients with surgically resectable colorectal cancer. After giving fully
informed consent, the prospective participants will undergo the classical combined modality
treatment according to NCCN guidelines. Serial analysis of ctDNA will be performed at
specific time points including pre-treatment, (post-NCRT for NCRT patients), postoperative
week 1, post-ACT, postoperative year 1, 2, and 3. The next-generation sequencing of surgical
specimens will be performed as well. Participants will be observed and examined during the
entire course of treatment and the follow-up period. The 3 year disease free survival
(3y-DFS) will be the primary end-point.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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||
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