Tooth Loss Clinical Trial
Official title:
Clinical and Histological Analysis of Soft Tissue Volume Gain and Stability Around Dental Implants Using Autogenous Subepithelial Connective Tissue Grafts Harvested From the Palate or Tuberosity. A Randomized Controlled Clinical Study
The goal of this study is to compare clinical and histologically the soft tissue changes in terms of volume gain and stability around dental implants in cases where a subepithelial connective tissue graft from the palate or from the tuberosity is used randomly
Understanding the importance of the soft tissue around implants have lead clinicians to
develop surgical approaches to augment it. The majority of them, are described as bilaminar
techniques obtaining a subephitelial connective tissue graft (SCTG) from the palate (P).
However, recent studies have demonstrated that tuberosity (T) tissue is a very dense and
coarse tissue that seems to contain more collagen and less fat and glandular tissue than
that from the P, and therefore may have better tissue qualities for soft tissue
augmentation, but there is limited scientific evidence comparing these areas.
The main goal of this study is to compare the soft tissue volume gain and stability around
implants in cases where a SCTG of the same dimensions from the P or T is used randomly. To
calculate volume changes and stability an intraoral optical scan is used and
three-dimensional images superimposed.
The secondary goal is to compare histologically both tissues and changes in clinical
parameters. Histomorphometry and immunohistochemistry evaluating levels of Type I-III
collagen, long lysyl hydroxylase, matrix metalloproteinase 1-2, and monoclonal antibody
against cytokeratin 4-10-13 is performed.
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