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Clinical Trial Summary

The question of how to administer adequate chemotherapy and immunotherapy to synchronise hypofraction radiotherapy (HFRT) treatment strategy to maximise the benefits of neoadjuvant therapy for the improved prognosis of patients with locally advanced rectal cancer (LARC).We aimed to study whether chemotherapy and tislelizumab plus split-course HFRT results in better outcomes in LARC patients.


Clinical Trial Description

Prior to analyzing continuous variables, the statistical normality of the data will be determined. The differences between the main variables will be compared by using the analysis of variance. A comparison of data on categorical variables will be carried out by χ2 tests or Fisher's exact tests. The OS and PFS was estimated using the Kaplan-Meier method. PFS and OS will be compared using the log-rank test. In cases where variables must be adjusted, we will use the proportional hazard Cox regression model. P values for all analyses will be based on using a significance level of 0.05. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05176964
Study type Observational
Source Fujian Medical University Union Hospital
Contact Benhua Xu
Phone 86+13696884375
Email benhuaxu@163.com
Status Recruiting
Phase
Start date December 31, 2021
Completion date December 31, 2025

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