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Radiation Exposure clinical trials

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NCT ID: NCT05804799 Completed - Liver Cancer Clinical Trials

Liver CT Dose Reduction With Deep Learning Based Reconstruction

Start date: January 1, 2021
Phase:
Study type: Observational [Patient Registry]

A deep learning-based de-noising (DLD) reconstruction algorithm (ClariCT.AI) has the potential to reduce image noise and improve image quality. This capability of the CliriCT.AI program might enable dose reduction for contrast-enhanced liver CT examination. In this prospective multicenter study, whether the ClariCT.AI program can reduce the noise level of low-dose contrast-enhanced liver CT (LDCT) data and therefore, can provide comparable image quality to the standard dose of contrast-enhanced liver CT (SDCT) images will be evaluated. The aim of this study is to compare image quality and diagnostic capability in detecting malignant tumors of LDCT with DLD to those of SDCT with MBIR using the predefined non-inferiority margin.

NCT ID: NCT05775601 Completed - Radiation Exposure Clinical Trials

18F-LY3950321-01 Biodistribution and Safety Study

Start date: February 28, 2023
Phase: Early Phase 1
Study type: Interventional

18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of 18F-LY3950321.

NCT ID: NCT05673473 Completed - Scoliosis Clinical Trials

Inter-variability in Radiographic Fluoroscopic Technique in Patients With Idiopathic Scoliosis

IVIS
Start date: January 1, 2016
Phase:
Study type: Observational

Radiographical images in Adolescent idiopathic scoliosis (AIS) can have a potential radiation-induced oncogenic effect. In this study, the investigators aim to compare a fluoroscopic imaging technique (LFT) with traditional radiographs for scoliosis (ORT), to see if LFT is adequate for clinical evaluation of AIS and having a lower radiation dose. Method Image quality will evaluated for LTF and ORT of phantom images and images from 3D printed models of AIS. The investigators will measure primary physical characteristics of noise, contrast, spatial resolution, SNR, and CNR. Three independent raters will evaluate the images by observer-based methods of ICS and VGAS. Radiation doses will be evaluated by DAP measurements. Two raters will perform measurements of 6 radiographic parameters for the LFT images of AIS

NCT ID: NCT05411172 Completed - Radiation Exposure Clinical Trials

Evaluation of a Model-Based CBRN Training Program

CBRN
Start date: January 1, 2020
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the effect of the Education Program based on the Mastery Learning Model for Chemical, Biological, Radiological, and Nuclear threats and hazards (MLM-CBRN Education Program) on student nurses' knowledge, attitude, self-efficacy, and skill development in chemical, biological, radiological and nuclear threats and hazards. The complete experimental design type was used in the study.

NCT ID: NCT05347290 Completed - Radiation Exposure Clinical Trials

Comparison Of Effective Radiation Shielding Between Rampart IC, M1128 Shield vs Conventional Apron And Shields In Clinical Interventional Procedures

RAMPART
Start date: March 9, 2022
Phase: N/A
Study type: Interventional

Previous studies have documented that orthopedic injuries and musculoskeletal pain are a likely result of wearing heavy leaded aprons. This single-center, randomized 1-3 month clinical study compares conventional lead aprons and ancillary shields to the Rampart IC, M1128 radiation protection system in order to improve radiation safety with minimal orthopedic strain by using the RAMPART device. There will be three study arms, each arm requiring 21 procedures for a total of 63 total procedures, Each procedure will be randomized, instead of individual subjects. Each enrolled subject may be involved in more than one procedure/case. Randomization stratification will be 1:1:1 to either Rampart shield only, lead apron and ancillary shield, or lead apron and Rampart Shield. Real-time dosimeters will be used in each procedure to measure radiation attenuation.

NCT ID: NCT04832633 Completed - Radiation Exposure Clinical Trials

The Best Parameters for Imaging Agent Injection and Scanning Methods in Computed Tomography Angiography

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Background: The contrast time-enhancement profiles of pulmonary artery (PA) and the aorta differ by using computed tomography (CT) angiography. Our purpose is to identify the optimal CT protocol for assessment of both vessels in one-time CT scan. Methods: The investigators prospectively enrolled 101 cases of CT angiography with suspicion of pulmonary embolism or aortic dissection in our center from 2018 to 2020. Forty cases receiving traditional two-time CT scans were collected retrospectively from 2015 to 2018. The investigators designed four groups: test bolus (TB) I, II and bolus-tracking (BT) I, II. The enhancement of the both vessels and the radiation dose of these four groups were collected. Traditional group was separated into traditional PA scan and traditional aorta scan. Data analyzed among the BT groups and the traditional groups were performed.

NCT ID: NCT04703933 Completed - Clinical trials for Knowledge, Attitudes, Practice

Knowledge and Attitude of the Operating Room Nurses About Radiation Exposure

Start date: August 1, 2016
Phase:
Study type: Observational

This study aims to evaluate the level of knowledge and attitude of the operating room nurses about radiation exposure.This descriptive study was conducted with 100 nurses working in the operating room of two university hospitals in Istanbul. Descriptive statistical analyses were performed using IBM SPSS 23 (Statistical Package for Social Sciences for Windows, Version 23.00, Armork NY).

NCT ID: NCT04689373 Completed - Dehydration Clinical Trials

Physical and Cognitive Effects of Fluoroscopy

Start date: June 30, 2021
Phase:
Study type: Observational [Patient Registry]

Background and objectives: The researchers will perform this study to reveal the clinical meaning of fatigue, headache, diarrhea, and impaired cognitive functions that are often expressed verbally in healthcare professionals who are exposed to fluoroscopy. Methods: After obtaining written informed consent, 84 samples will be included in the study. For operating room employees who meet the criteria determined before and after the operation; mini-mental state examination, weight, heart rate, non-invasive blood pressure value, VAS score for headache, radiation exposure time on fluoroscopy device, Rad measurement with the help of personal dosimeter before and after surgery, and total time in the operating room will be recorded.

NCT ID: NCT04404257 Completed - Radiation Exposure Clinical Trials

Reduce Radiation Exposure in Fluoroscopic Interventions Evaluation

REDEFINE
Start date: November 5, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the ControlRad system device when installed in Fluoroscopic (x-ray) machine reduces radiation dose to operators (Doctors and nurses) and to the patient who is undergoing cardiac Catheterization and electrophysiology (EP) implant procedures.

NCT ID: NCT04363190 Completed - Radiation Exposure Clinical Trials

Genomic Instability in Vascular Surgeons

IRADIENT
Start date: November 9, 2018
Phase:
Study type: Observational

The past two decades have witnessed the development and growth of the endovascular techniques, however, this new technology is not exempt from risks, since its use requires an ionizing radiation exposure to both patients and surgeons. In this context, the long-term repercussion of this type of chronic exposure to low dose ionizing radiation of the vascular surgeons is still unknown. Although conventional dosimetry is used to monitoring the occupational radiation exposure, it doesn't take into consideration a number of individual variables such as: age, sex, exposure to other carcinogen substances or previous medical history; that may affect the radio-sensibility of each individual. Some studies suggest the use of routine cytogenetic analysis to complement the conventional dosimetry, yet the real genomic effects of chronic low dose ionizing radiation exposure is still unclear and an ideal biodosimetry marker hasn't been described. In this setting, the main objective of the present study was to determine the genomic instability associated to the chronic low dose exposure to ionizing radiation of vascular surgeons versus healthy control patients with no history of radiation exposure. The secondary endpoints were to determine the impact of demographic and clinical practice activities associated to genomic instability among both groups of patients. National, observational and transversal case control study of genomic instability among vascular surgeons chronically exposed to low dose ionizing radiation compared to healthy control patients with no previous history of radiation exposure. The peripheral blood samples of the case group were collected from vascular surgeons during the VI International Symposium of Endovascular Surgery. The blood samples were followed by a demographic and endovascular practice questionnaire. On the other hand, the samples for the control group were collected from healthy patients undergoing saphenectomy and/or phlebectomy in our department at Hospital Clínico Universitario de Valladolid. All blood samples were send to the Cancer Investigation Center at Salamanca University where three types of genomic analysis were performed: (1) fluorescence in situ hybridization (FISH) study in interphase for the chromosomes 3, 7 and 17 and locus 9p21; (2) metaphase study with G banding technique; and (3) sister chromatid exchange (SCE) metaphase study.