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Purpura, Thrombocytopenic clinical trials

View clinical trials related to Purpura, Thrombocytopenic.

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NCT ID: NCT05492409 Completed - Clinical trials for Idiopathic Thrombocytopenic Purpura

Study of the Safety and Immunogenicity of Long-term GNR-069 Therapy in ITP Patients

Start date: March 28, 2022
Phase: Phase 3
Study type: Interventional

It is a phase III extension study to assess safety and immunogenicity of long-term therapy with GNR-069 in patients with idiopathic thrombocytopenic purpura

NCT ID: NCT05263193 Completed - Clinical trials for Immune-mediated Thrombocytopenic Purpura

Retrospective Study on Caplacizumab-treated Pediatric Patients With Immune-mediated Thrombocytopenic Purpura (iTTP)

Start date: June 8, 2022
Phase:
Study type: Observational

The purpose of this multi-country, retrospective data collection study (chart review) is to describe the effectiveness and safety of caplacizumab in pediatric patients with iTTP.

NCT ID: NCT05220878 Completed - Clinical trials for Idiopathic Thrombocytopenic Purpura

Comparative Study of Clinical Efficacy and Safety of GNR-069 and Nplate in Patients With ITP

Start date: September 9, 2021
Phase: Phase 3
Study type: Interventional

It is a phase III multicenter randomized double-blinded comparative study of clinical efficacy and safety of GNR-069 and Nplate in patients with idiopathic thrombocytopenic purpura

NCT ID: NCT04132050 Completed - Clinical trials for Idiopathic Thrombocytopenic Purpura

A Clinical Study in Patients With Chronic Idiopathic Thrombocytopenic Purpura in R788

Start date: December 24, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy, safety and pharmacokinetics of R788 compared with placebo, and to investigate the safety and efficacy of long term dosing of R788 in patients with chronic idiopathic thrombocytopenic purpura.

NCT ID: NCT04074187 Completed - Clinical trials for Thrombotic Thrombocytopenic Purpura

A Trial of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)

Start date: October 21, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Primary Objective: To evaluate the effect of caplacizumab on prevention of recurrence of aTTP (proportion of participants with a recurrence of aTTP) during the overall study period. Secondary Objectives: - To evaluate effect of caplacizumab on - prevention of recurrence of TTP (the number of recurrences of TTP) during overall study period. - a composite endpoint consisting of aTTP-related mortality, recurrence of aTTP and major thromboembolic events during study drug treatment - restoring platelet counts as a measure of prevention of further microvascular thrombosis - refractory disease - biomarkers of organ damage: LDH, cardiac troponin I, serum creatinine - plasma exchange (PE) parameters (days of PE and volume of plasma used), days in intensive care unit, days in hospital - cognitive status of Japanese patients - To evaluate safety profile of caplacizumab in Japanese patients - To evaluate effect of caplacizumab on pharmacodynamic (PD) markers in Japanese patients - To evaluate pharmacokinetic (PK) profile of caplacizumab in Japanese patients - To evaluate immunogenicity of caplacizumab in Japanese patients

NCT ID: NCT04071496 Completed - Clinical trials for Chronic Idiopathic Thrombocytopenic Purpura

Diagnostic of Chronic Thrombocytopenia

DIATROC
Start date: November 25, 2009
Phase:
Study type: Observational

The objective of this study is to provide simple and relevant clinical and biological elements to distinguish a possible Congenital Thrombocytopenia from a Chronic Idiopathic Thrombocytopenic Purpura .

NCT ID: NCT04070612 Completed - Cytopenia Clinical Trials

National Prospective Cohort for Monitoring Children With Severe Autoimmune Cytopenia.

BIOCEREVANCE
Start date: April 4, 2007
Phase:
Study type: Observational

This study aims to study prospectively the clinical and paraclinical evolution and prognostic factors of autoimmune haemolytic anemias, Evans syndromes and chronic immunological thrombocytopenic purpura of children in France.

NCT ID: NCT04070599 Completed - Clinical trials for Immune Thrombocytopenic Purpura

Initial Hemato-immunological Profile on the Evolution of Immunological Thrombopenic Purpura.

IMMUNOTI
Start date: April 12, 2011
Phase: Phase 3
Study type: Interventional

This study aims to determine the hemato-immunological parameters predictive of the evolution of a Immune thrombocytopenic purpura (ITP) towards chronicity, and to identify possible differences between the child and the adult.

NCT ID: NCT04057703 Completed - Immunotherapy Clinical Trials

Balance Benefit / Risk of Immunomodulatory Treatments at the Child and Adolescent for Autoimmune Cytopenia.

VIGICAIRE
Start date: January 18, 2016
Phase:
Study type: Observational

In France, a national prospective cohort for monitoring children and adolescents with autoimmune cytopenia OBS'CEREVANCE is in place since 2004. It is coordinated in Bordeaux by the Center's team. Reference Rare Diseases CEREVANCE. It has been validated by the French Data Protection Authority in 2009 (information note and written consent). It had mid 2013 more of 900 patients, and the data collected make it possible to study intentionally to treat the therapeutic management of patients with Chronic Immune-Thrombocytopenic Purpura, from Autoimmune Hemolytic Anemia, or from EVANS syndrome. This study evaluates efficacy and tolerance at 6 months of treatment immunomodulators prescribed in France in real conditions of use, in children and adolescents under the age of 18, for a Chronic Immune-Thrombocytopenic Purpura, an Autoimmune Hemolytic Anemia or a simultaneous EVANS syndrome.

NCT ID: NCT04056507 Completed - Clinical trials for Immune Thrombocytopenic Purpura

Immunological Markers in Adult Patients With Immune Thrombocytopenic Purpura

SPLENOTIR
Start date: April 12, 2012
Phase:
Study type: Observational

The aim of this study is to determine histological immunological parameters, sought on splenectomy pieces that may explain the failure or success of splenectomy in patients with ITP who had a splenectomy to treat their ITP(Immune thrombocytopenic purpura).