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Pulpitis clinical trials

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NCT ID: NCT04585438 Not yet recruiting - Postoperative Pain Clinical Trials

Evaluation of Trans-mucosal Bio-adhesive Discs of Diclofenac Potassium on the Anesthetic Success and Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Start date: September 21, 2021
Phase: Phase 4
Study type: Interventional

The aim of the proposed study is to compare the effect of single dose of Diclofenac Potassium premedication as trans-mucosal bio-adhesive discs versus placebo on the effectiveness of the inferior alveolar nerve block and postoperative pain in patients with symptomatic irreversible pulpitis.

NCT ID: NCT04573374 Not yet recruiting - Clinical trials for Irreversible Pulpitis

Comparing the Outcome of Pulpotomy Using Biodentine and Portland Cement in Mature Cases With Irreversible Pulpitis: Randomized Clinical Trial

Start date: November 2020
Phase: N/A
Study type: Interventional

The aim of the study is to compare the treatment outcome of pulpotomy using Biodentine or Portland cement regarding success rate and post-operative pain.

NCT ID: NCT04561921 Not yet recruiting - Clinical trials for Success of Inferior Alveolar Nerve Block

Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.

Start date: October 22, 2020
Phase: N/A
Study type: Interventional

the study is conducted to assess the effect of adding magnesium sulphate to mepivacaine HCl compared to mepivacaine HCl alone on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis in mandibular molars

NCT ID: NCT04319549 Not yet recruiting - Clinical trials for Acute Irreversible Pulpitis With Apical Periodontitis

Ketorolac Irrigant on Post Operative Pain

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

Endodontic post-treatment pain management is one of the most challenging problems in the clinical practice of endodontics. Although this pain is decreased after root canal treatment, there may be residual symptoms due to inflammation. It has been reported that up to 80% of patients with preoperative pain, will report pain after endodontic treatment, which might range from mild to severe. Management of endodontic pain should involve all steps of treatment including preoperative pain control through accurate diagnosis and reduction of anxiety, intraoperative pain control through effective and profound local anesthetic, operative techniques and that can be achieved through a variety of pharmacologic agents. Many mechanisms have been proposed to explain the reason for postoperative pain including the sensitization of nociceptors by inflammatory mediators. Among these chemical inflammatory mediators are the prostaglandins which is the terminal product of arachidonic acid metabolism, through the cyclooxygenase (COX) pathway. Endodontic treatment can cause the release of inflammatory mediators (e.g. prostaglandins, leukotrienes, bradykinin, platelet- activating factor and substance P) into the surrounding periapical tissues, causing pain fibers to be directly stimulated (by bradykinin for instance) or sensitized (by prostaglandins). In addition, the vascular dilation and increased permeability as a consequence of periradicular inflammation, cause edema and increased interstitial tissue response. Single-visit root canal treatment is common in some endodontic practices. However, one of the main concerns with this approach has been the fear of post- operative pain. Mechanical, chemical and microbiological injuries to the peri- radicular tissues during root canal treatment have been suggested as possible causes of post-operative pain. The role of irrigating solutions used during root canal treatment to help control post-operative pain is unclear. While certain studies have observed a reduction in post-operative pain with particular types and concentrations of irrigating solutions, other studies have reported no difference in post-operative pain with the different irrigating solutions .

NCT ID: NCT03916900 Not yet recruiting - Clinical trials for Pulpitis - Irreversible

Postoperative Pain and Success Rate in Pulpotomy Versus Root Canal Treatment

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

Pulpotomy has been proposed in the last decade as a definitive treatment of mature permanent teeth with irreversible pulpitis due to the better understanding of the pulp biology and development of bioactive materials . This technique involves removal of the coronal portion of the pulp that has undergo degenerative and irreversible changes to the level of the canal orifices and leaving the healthy vital radicular portion of the pulp. The surrogate marker for the degree of inflammation and the healing potential of the remaining pulp tissue has been suggested to be the ability to control the bleeding after pulp amputation. By preserving the pulp vitality, this can help in maintaining proprioceptive, reparative, innervation (tooth sensitivity), vascularization, and damping functions. The vital pulp can continue to serve the function of protecting the tooth from overload by means of protective feedback mechanism and preventing fracture because of the presence of pulp and organic tissue in the dentinal tubules..

NCT ID: NCT03890835 Not yet recruiting - Clinical trials for Symptomatic Irreversible Pulpitis

Pulpotomy in Mature Permanent Molars Using Biodentine Versus MTA

Start date: May 2019
Phase: N/A
Study type: Interventional

The aim of this study is to compare treatment outcomes of pulpotomy in mature permanent teeth using Biodentine versus MTA regarding postoperative pain and success rate.

NCT ID: NCT03745105 Not yet recruiting - Postoperative Pain Clinical Trials

Comparative Evaluation of the Effect of Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

Start date: December 25, 2018
Phase: N/A
Study type: Interventional

the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and NSAID(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.

NCT ID: NCT03716635 Not yet recruiting - Clinical trials for Symptomatic Irreversible Pulpitis

Effect of Cryotherapy on Postoperative Pain

Start date: November 2018
Phase: N/A
Study type: Interventional

the aim of the study is to evaluate the effect of cryotherapy on postoperative pain in molar teeth with irreversible pulpitis and apical periodontitis

NCT ID: NCT03694743 Not yet recruiting - Pulpitis Clinical Trials

Post-operative Pain in 2Shape Versus Protaper Next Rotary Systems

Start date: December 2018
Phase: N/A
Study type: Interventional

Pain after endodontic treatment is considered the most disturbing problem facing both the patient and the dentist especially in cases of symptomatic pulpitis as the patient is expecting to relief the pain that already exists.Therefore, this study aims to find a solution for the post-operative pain felt by the patient with symptomatic pulpitis in mandibular molars through comparing post-operative pain following use of 2Shape and Protaper Next rotary systems.

NCT ID: NCT03612323 Not yet recruiting - Clinical trials for Pulpitis - Irreversible

Comparison Between Intraligamentary Piroxicam and Articaine

Start date: November 2018
Phase: Early Phase 1
Study type: Interventional

Comparing the efficacy of intra-ligamentary Piroxicam and intra-ligamentary Articaine on pain during and after endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.