Pulmonary Ventilation; Newborn, Abnormal Clinical Trial
Official title:
Influence of Different PEEP Levels and Different Tidal Volumes on Regional Pulmonary Function in Patients Undergoing Robot Assisted Prostatectomy Detected by Electrical Impedance Tomography
Mechanical ventilation is indispensable for most of surgical interventions but can induce
lung injury even in pulmonary healthy patients. This can lead to postoperative pulmonary
complications. These adverse effects could be prevented by a better monitoring of
intraoperative lung function. Electrical impedance tomography is able to visualize aeration
within the lung in real time.
The planned study investigates the influence of different levels of positive endexspiratory
pressure and different tidal volumes on the aeration.
Available perioperative parameters to set mechanical ventilation parameters represent only
global lung function. But to reduce postoperative pulmonary complications induced by
mechanical ventilation a better monitoring of intraoperative lung function seems to be
crucial, that provides more regional information of lung collapse or over distention.
By application of small currents via electrodes around the thorax and measuring of the
resultant resistance the electrical impedance tomography (EIT) can determine the level of
aeration of the lung in a cross sectional plane. The EIT device used in this study calculates
the percentage of the investigated lung area that can be defined as over distended or
collapsed respectively. In these sections the change of resistance within a respiration cycle
is reduced compared to well ventilated areas are therefore called silent spaces. Silent
spaces located ventral are termed non-dependent (NSS) and silent spaces located dorsal are
termed dependent (DSS). Based on this information the clinician is able to set the respirator
in a more lung protective manor.
To better understand the influence of positive endexspiratory pressure (PEEP) and tidal
volume (Vt) on reginal lung function we are going to carry out the presented study.
40 patients undergoing robot assisted prostatectomy should be enrolled in a study that
consists of two phases. In the first phase 20 patients are ventilated with constant PEEP
(10mbar) and in ten patients each the Vt is set to 5 or 12ml/kg ideal body weight. In the
second phase in further 20 patients the Vt is set to 8ml/ kg ideal bodyweight and the PEEP is
3 or 12mbar in one half of the patients. Under the different ventilation settings the NSS and
DSS, the oxygenation index and lung compliance will be investigated.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00810186 -
Continuous Monitoring of Lung Ventilation
|
N/A |