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Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation

Pulmonary Infection Clinical Trial

Official title:
Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation

Clinical Trial Summary

One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04583046
Study type Interventional
Source Yonsei University
Contact Young Jun Oh
Phone +82-2-2228-2423
Email yjoh@yuhs.ac
Status Not yet recruiting
Phase N/A
Start date October 2020
Completion date August 2022
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