Type 2 Diabetes Mellitus Clinical Trial
Official title:
Liaoning University of Traditional Chinese Medicine
To investigate the protective effect of calcium dobesilate, Xuefuzhuyu Decoction, calcium dobesilate combined with Xuefuzhuyu Decoction on the early lung function of type 2 diabetes mellitus
Test group and treatment: the patients with type 2 diabetes mellitus were randomly divided
into calcium dobesilate group, Xuefuzhuyu Decoction group and combination group. All
participants were given hypoglycemic, metformin (1000 mg, bid, PO), Mecobalamin Tablets,
nerve nutrition (0.5 mg bid, PO): treatment. Calcium dobesilate group were given
hypoglycemic, metformin (500 mg tid, PO), to improve the circular Calcium Dobesilate
Capsules (0.5 g bid, PO), Mecobalamin Tablets, nerve nutrition (0.5 mg bid, PO): treatment.
Xuefuzhuyu Decoction group was given hypoglycemic, metformin (500 mg tid, PO), to improve
the circular Xuefuzhuyu Decoction (100 ml bid, PO), Mecobalamin Tablets, nerve nutrition
(0.5 mg bid, PO): treatment. The combined treatment group was given metformin hypoglycemic
(500 mg tid, PO), Calcium Dobesilate Capsules, improve circulation (0.5 g bid, PO) +
Xuefuzhuyu Decoction (100 ml, bid, PO), Mecobalamin Tablets, nerve nutrition (0.5 mg bid,
PO). Before treatment, three groups of patients with blood glucose, oxidation related
indicators, retrobulbar hemodynamics and pulmonary function were recorded.
Detection: continuous treatment were observed before and after treatment of the three groups
of patients after 24 weeks of fasting blood glucose (FBG), 2 hour postprandial blood glucose
(2hPBG), body mass index (BMI), peripheral blood glycated hemoglobin (HbA1c) and related
indexes of oxidation, superoxide dismutase (SOD), glutathione peroxidase, Gu Guang (GSH-Px),
reactive oxygen species (ROS) activity, malondialdehyde (MDA) concentration and pulmonary
function, vital capacity (VC%), forced vital capacity (FVC%), one second forced expiratory
flow (FEV1%), peak expiratory flow (PEF%), maximal voluntary ventilation (MVV%), total lung
capacity (TCL%) and a second rate (FEV1/FVC%), diffusion capacity of the lung for carbon
monoxide (DLCO%), lung volume diffusion capacity of carbon monoxide (DLCO/VA%) changes of
the central retinal artery (CRA) and posterior ciliary artery (PCA), eye movement The
changes of blood flow velocity and resistance index (RI) of the pulse (AO) systolic and
diastolic blood flow were recorded.
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