Pulmonary Emphysema Clinical Trial
Official title:
Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema
Actively developing stem cells (SCs) transplantation techniques cause natural interest to the
problem of regeneration in the lungs. Numerous experimental studies proved the benefits of
different types of SCs in experimental models of pulmonary emphysema (PE).
G. Zhen et al. have shown that the transplantation of mesenchymal stem cells (MSCs) to rats
with papain-induced emphysema leads to their migration into the lungs, differentiation into
type 2 alveolocytes, and inhibition of apoptosis and prevention PE.
K. Schweitzer et al. have proved the activity of inflammation in the airways, alveolocytes
and endothelial cells apoptosis decreased after adipose SCs intravenous administration to
mice with emphysema caused by chronic exposure to tobacco smoke or VEGF receptors blockade.
The study of E.P. Ingenito et al. found that endobronchial installed MSCs engraft into the
alveolar wall and peribronchial interstitium and release integrins, extracellular matrix
components (collagen IV, laminin and fibrillin), platelet-derived growth factor receptor and
transforming growth factor β2.
Our study also found reliable deterrent effect of allogeneic bone marrow MSCs on the
development of elastase-induced emphysema in rats at different terms of transplantation.
After the success of pilot studies have started clinical trials. Currently, the website
http://www. ClinicalTrials.gov reported three studies evaluating the efficacy and safety of
MSC transplantation in patients with COPD and emphysema. Two of them have already been
completed and the results of the first pilot project published.
Authors on the example of 4 patients showed a complete absence of adverse effects, improved
quality of life and stability of functional parameters at 12 months after starting treatment
One of the problems of MSC transplantation in patients with respiratory failure is an
accelerated apoptosis of transplanted cells under the influence of proinflammatory cytokines
and oxidative stress. Since it is proved that preconditioning MSCs under hypoxia increases
their survival in hypoxic conditions, increases the expression of growth factors and
antiinflammatory cytokines, we suppose that MSCs grown in hypoxic medium may have a
significant positive effect on the disease.
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