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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT00613860 Withdrawn - COPD Clinical Trials

Sequential Endoscopic Lung Volume Reduction

Start date: January 2008
Phase: Phase 3
Study type: Interventional

Patients with heterogenous emphysema benefits from endoscopic lung volume reduction. Until now the technique is limited to one lobe. In case of collateral ventilation patients show no improvement. Between upper and middle lobe exists the highest collateral flow. The trial examine the hypothesis, that sequential ELVR help especially those patients, which have no benefit after lobar exclusion.

NCT ID: NCT00608764 Active, not recruiting - Clinical trials for Pulmonary Disease, Chronic Obstructive

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

COPDGene
Start date: November 2007
Phase:
Study type: Observational

Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.

NCT ID: NCT00570544 Completed - COPD Clinical Trials

Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema

Start date: August 2004
Phase: Phase 4
Study type: Observational

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.

NCT ID: NCT00566839 Completed - Pulmonary Emphysema Clinical Trials

Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery

Start date: December 2002
Phase: Phase 2
Study type: Interventional

Lung volume reduction surgery is effective in improving pulmonary function and quality of life in selected patients with severe emphysema although the morbidity of this surgical procedure is still considerable. Morbidity is mainly addressed to general anesthesia-related adverse effects and surgical trauma deriving from lung resection. Having developed an awake nonresectional lung volume reduction surgery technique, which is performed under sole thoracic epidural anesthesia, we have hypothesized that it could offer satisfactory clinical results and reduced morbidity rate when compared with the conventional surgical procedure.

NCT ID: NCT00528944 Completed - Emphysema Clinical Trials

Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity

Start date: January 2006
Phase: N/A
Study type: Observational

Although single breath helium (He) dilution measurement (VASB) is currently used in pulmonary function laboratories to assess functional alveolar volume and diffusing capacity for carbon monoxide, the extent to which VASB reflects ventilatory and thoracic volume has not been prospectively determined in emphysema. We hypothesized that VASB underestimates rebreathe helium dilution volume (VARB), and plethysmographic volume (VApleth) as clinical and physiologic severity of emphysema increases.

NCT ID: NCT00517998 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study

Start date: May 2007
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of the Biologic Lung Volume Reduction System (BLVR) for patients with advanced emphysema refractory to medical therapy.

NCT ID: NCT00515164 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study

Start date: August 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study it to evaluate the efficacy and safety of the 20 mL BLVR System in patients with advanced upper lobe predominant emphysema.

NCT ID: NCT00475007 Completed - COPD Clinical Trials

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

IBV®Valve
Start date: September 2007
Phase: N/A
Study type: Interventional

This trial is for men and women between the ages of 40 and 74 who have a confirmed diagnosis of emphysema. The objective of the trial is to determine the safety and effectiveness of the IBV Valve at redirecting airflow from diseased portions of the lung to healthier areas to achieve improvement in disease-related health status.

NCT ID: NCT00435253 Completed - Pulmonary Emphysema Clinical Trials

US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study

Start date: February 2007
Phase: Phase 2
Study type: Interventional

Evaluate the efficacy and safety of the 10 mL BLVR System in 1 or 2 treatment sessions (8 subsegments, 4 in each lung) in patients with advanced upper lobe predominant emphysema.

NCT ID: NCT00413205 Completed - Emphysema Clinical Trials

TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)

Start date: January 2007
Phase: Phase 2
Study type: Interventional

This 2 arm study will investigate the efficacy, safety and tolerability of RAR Gamma versus placebo in ex-smokers with moderate or severe emphysema treated with optimal COPD therapy. Following optimization of COPD therapy (up to 6 weeks) patients will be randomized to receive either RAR Gamma (5mg) or placebo once daily using a 2:1 ratio (active:placebo), in addition to their standard therapy. Following the double-blind treatment period, patients will enter a 4-week follow-up period. The anticipated time on study period is 1-2 years, and the target sample size is 100-500 individuals.