Pulmonary Disease Clinical Trial
Official title:
The Effect of a Pulmonary Rehabilitation on Lung Function and Exercise Capacity in Patients With Burn: a Prospective Randomized Single Blind Study
Verified date | October 2019 |
Source | Hangang Sacred Heart Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Inhalation burn injury and lung complications caused by large surface burns occurring during
a fire remains a serious problem. Pulmonary rehabilitation has been used successfully to
improve pulmonary function(PF) in patients with chronic obstructive pulmonary disease. But
there were no studies that pulmonary rehabilitation induce improvements in PF in patient with
large surface burn and inhalation injury.
The investigators will performe pulmonary function and respiratory muscles strength
evaluation in 40 patients with thermal injury in order to evaluate the effects of pulmonary
rehabilitation in patients with thermally injury.
Status | Completed |
Enrollment | 120 |
Est. completion date | January 30, 2020 |
Est. primary completion date | January 10, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - inhalation injury - The burn surface area of chest and neck are more than 50% of the anterior or posterior trunk areas. Exclusion Criteria: - vocal cord palsy - who were intubated - had a tracheostomy - anoxic brain injury - psychologicical disorders - quadriplegia - severe cognitive disorders - who took medications that affect pulmonary function. |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Hangang Sacred Heart Hospital | Seoul | Yeong-deungpo-Dong |
Lead Sponsor | Collaborator |
---|---|
Hangang Sacred Heart Hospital | Hallym University, National Research Foundation of Korea |
Korea, Republic of,
Al-Mousawi AM, Williams FN, Mlcak RP, Jeschke MG, Herndon DN, Suman OE. Effects of exercise training on resting energy expenditure and lean mass during pediatric burn rehabilitation. J Burn Care Res. 2010 May-Jun;31(3):400-8. doi: 10.1097/BCR.0b013e3181db — View Citation
Ring J, Heinelt M, Sharma S, Letourneau S, Jeschke MG. Oxandrolone in the Treatment of Burn Injuries: A Systematic Review and Meta-analysis. J Burn Care Res. 2020 Jan 30;41(1):190-199. doi: 10.1093/jbcr/irz155. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | FVC | forced vital capacity(%) | 12 weeks | |
Primary | FEV1 | 1 second forced expiratory volume(%) | 12 weeks | |
Primary | FEV1/FVC ratio | FEV1/FVC ratio expressed as a percentage(%) | 12 weeks | |
Secondary | MEP | maximal expiratory pressure | 12 weeks | |
Secondary | MIP | maximal inspiratory pressure | 12 weeks | |
Secondary | gait performance | 6-minute walk test | 12 weeks |
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